Glaucoma secondary to drugs

H7_GLAUCSECDRUG

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H40.6#
  • Hospital discharge: ICD-9 3653A
  • Cause of death: ICD-10 H40.6#
  • Cause of death: ICD-9 3653A

2 out of 7 registries used, show all original rules.

100

4. Check minimum number of events

None

100

5. Include endpoints

None

100

6. Filter based on genotype QC (FinnGen only)

99

Control definitions (FinnGen only)

Control exclude H7_GLAUCOMA

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H40
Name in latin Glaucoma ex usu medicamenti

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 667 340 320
Only index persons 593 307 286
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 54.35 54.38 54.37
Only index persons 52.80 52.63 52.98

-FinnGen-

Key figures

All Female Male
Number of individuals 99 48 51
Unadjusted period prevalence (%) 0.02 0.02 0.03
Median age at first event (years) 53.45 51.13 55.63

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint H7_GLAUCSECDRUG and mortality.

Females

Parameter HR [95% CI] p-value
H7_GLAUCSECDRUG 1.913 [1.39, 2.64] < 0.001
Birth year 0.994 [0.98, 1.0] 0.14

During the follow-up period (1.1.1998 — 31.12.2019), 65 out of 267 females with H7_GLAUCSECDRUG died.

Males

Parameter HR [95% CI] p-value
H7_GLAUCSECDRUG 1.552 [1.14, 2.11] 0.005
Birth year 0.988 [0.98, 1.0] 0.018

During the follow-up period (1.1.1998 — 31.12.2019), 59 out of 245 males with H7_GLAUCSECDRUG died.

Mortality risk

Mortality risk for people of age

years, who have H7_GLAUCSECDRUG.

N-year risk Females Males
1 0.161% 0.328%
5 1.124% 1.904%
10 2.803% 4.702%
15 5.382% 8.75%
20 9.14% 14.514%

Relationships between endpoints

Index endpoint: H7_GLAUCSECDRUG – Glaucoma secondary to drugs

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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