Glaucoma

H7_GLAUCOMA

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H40-H42
  • Cause of death: ICD-10 H40-H42

2 out of 7 registries used, show all original rules.

23354

4. Check minimum number of events

None

23354

5. Include endpoints

24381

6. Filter based on genotype QC (FinnGen only)

23483

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 233920 143708 88340
Only index persons 193946 120923 73023
Unadjusted period prevalence (%)
Whole population 3.48 4.12 2.47
Only index persons 3.82 4.45 2.79
Median age at first event (years)
Whole population 68.10 68.91 66.78
Only index persons 67.32 68.15 65.94

-FinnGen-

Key figures

All Female Male
Number of individuals 23483 13545 9938
Unadjusted period prevalence (%) 5.18 5.32 4.99
Median age at first event (years) 66.29 65.57 67.26

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint H7_GLAUCOMA and mortality.

Females

Parameter HR [95% CI] p-value
H7_GLAUCOMA 0.927 [0.86, 1.0] 0.046
Birth year 0.992 [0.98, 1.0] 0.05

During the follow-up period (1.1.1998 — 31.12.2019), 24916 out of 98423 females with H7_GLAUCOMA died.

Males

Parameter HR [95% CI] p-value
H7_GLAUCOMA 0.94 [0.86, 1.02] 0.154
Birth year 0.994 [0.99, 1.0] 0.13

During the follow-up period (1.1.1998 — 31.12.2019), 16495 out of 60846 males with H7_GLAUCOMA died.

Mortality risk

Mortality risk for people of age

years, who have H7_GLAUCOMA.

N-year risk Females Males
1 0.067% 0.183%
5 0.499% 1.275%
10 1.171% 3.165%
15 2.168% 5.955%
20 3.707% 10.966%

Relationships between endpoints

Index endpoint: H7_GLAUCOMA – Glaucoma

GWS hits: 81

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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