glaucoma: Increased pressure in the eyeball due to obstruction of the outflow of aqueous humor.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
23354 |
4. Check minimum number of eventsNone |
23354 |
5. Include endpoints |
24381 |
6. Filter based on genotype QC (FinnGen only) |
23483 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Summary Statistics
↥-FinRegistry-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | |||
Whole population | 233920 | 143708 | 88340 |
Only index persons | 193946 | 120923 | 73023 |
Unadjusted period prevalence (%) | |||
Whole population | 3.48 | 4.12 | 2.47 |
Only index persons | 3.82 | 4.45 | 2.79 |
Median age at first event (years) | |||
Whole population | 68.10 | 68.91 | 66.78 |
Only index persons | 67.32 | 68.15 | 65.94 |
-FinnGen-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | 23483 | 13545 | 9938 |
Unadjusted period prevalence (%) | 5.18 | 5.32 | 4.99 |
Median age at first event (years) | 66.29 | 65.57 | 67.26 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H7_GLAUCOMA and mortality.
Females
Parameter | HR [95% CI] | p-value |
---|---|---|
H7_GLAUCOMA | 0.927 [0.86, 1.0] | 0.046 |
Birth year | 0.992 [0.98, 1.0] | 0.05 |
During the follow-up period (1.1.1998 — 31.12.2019), 24916 out of 98423 females with H7_GLAUCOMA died.
Males
Parameter | HR [95% CI] | p-value |
---|---|---|
H7_GLAUCOMA | 0.94 [0.86, 1.02] | 0.154 |
Birth year | 0.994 [0.99, 1.0] | 0.13 |
During the follow-up period (1.1.1998 — 31.12.2019), 16495 out of 60846 males with H7_GLAUCOMA died.
Mortality risk
Mortality risk for people of age
years, who have H7_GLAUCOMA.N-year risk | Females | Males |
---|---|---|
1 | 0.067% | 0.183% |
5 | 0.499% | 1.275% |
10 | 1.171% | 3.165% |
15 | 2.168% | 5.955% |
20 | 3.707% | 10.966% |
Relationships between endpoints
↥Index endpoint: H7_GLAUCOMA – Glaucoma
GWS hits: 81