primary angle closure glaucoma: The sudden increase of intraocular pressure, resulting in pain and an abrupt decrease in visual acuity.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1480 |
4. Check minimum number of eventsNone |
1480 |
5. Include endpointsNone |
1480 |
6. Filter based on genotype QC (FinnGen only) |
1416 |
Control definitions (FinnGen only)
Extra metadata
Similar endpoints
↥List of similar endpoints to Primary angle-closure glaucoma based on the number of shared cases.
Similar with more cases:
- Glaucoma
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥Summary Statistics
↥-FinRegistry-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | |||
Whole population | 17902 | 11851 | 5834 |
Only index persons | 13200 | 8791 | 4409 |
Unadjusted period prevalence (%) | |||
Whole population | 0.28 | 0.34 | 0.16 |
Only index persons | 0.27 | 0.32 | 0.17 |
Median age at first event (years) | |||
Whole population | 68.78 | 69.73 | 66.90 |
Only index persons | 67.76 | 68.71 | 65.87 |
-FinnGen-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | 1416 | 822 | 594 |
Unadjusted period prevalence (%) | 0.31 | 0.32 | 0.30 |
Median age at first event (years) | 66.02 | 65.69 | 66.48 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H7_GLAUCCLOSEPRIM and mortality.
Females
Parameter | HR [95% CI] | p-value |
---|---|---|
H7_GLAUCCLOSEPRIM | 1.071 [0.99, 1.16] | 0.085 |
Birth year | 0.992 [0.98, 1.0] | 0.045 |
During the follow-up period (1.1.1998 — 31.12.2019), 2692 out of 7308 females with H7_GLAUCCLOSEPRIM died.
Males
Parameter | HR [95% CI] | p-value |
---|---|---|
H7_GLAUCCLOSEPRIM | 1.093 [0.98, 1.22] | 0.115 |
Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 1312 out of 3811 males with H7_GLAUCCLOSEPRIM died.
Mortality risk
Mortality risk for people of age
years, who have H7_GLAUCCLOSEPRIM.N-year risk | Females | Males |
---|---|---|
1 | 0.064% | 0.193% |
5 | 0.526% | 1.222% |
10 | 1.319% | 3.23% |
15 | 2.475% | 5.968% |
20 | 4.646% | 9.811% |
Relationships between endpoints
↥Index endpoint: H7_GLAUCCLOSEPRIM – Primary angle-closure glaucoma
GWS hits: -