glaucoma: Increased pressure in the eyeball due to obstruction of the outflow of aqueous humor.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
275 |
4. Check minimum number of eventsNone |
275 |
5. Include endpointsNone |
275 |
6. Filter based on genotype QC (FinnGen only) |
263 |
Control definitions (FinnGen only)
Control exclude
H7_GLAUCOMA
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF6
Parent code in ICD-10
H40
Name in latin
Glaucoma [secundarium] postinflammatorium
Similar endpoints
↥List of similar endpoints to
Glaucoma secondary to eye inflammation
based on the number of shared cases.
Similar with more cases:
- Glaucoma
- Diseases of the eye and adnexa
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2511 | 1296 | 1195 |
| Only index persons | 2084 | 1092 | 992 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.03 |
| Only index persons | 0.04 | 0.04 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 50.74 | 54.42 | 46.51 |
| Only index persons | 47.68 | 51.18 | 43.82 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 263 | 141 | 122 |
| Unadjusted period prevalence (%) | 0.06 | 0.06 | 0.06 |
| Median age at first event (years) | 49.74 | 50.25 | 49.16 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint H7_GLAUCSECINFLAM and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_GLAUCSECINFLAM | 1.399 [1.15, 1.7] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.129 |
During the follow-up period (1.1.1998 — 31.12.2019), 148 out of 753 females with H7_GLAUCSECINFLAM died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_GLAUCSECINFLAM | 1.0 [0.79, 1.26] | 0.997 |
| Birth year | 0.987 [0.98, 1.0] | 0.007 |
During the follow-up period (1.1.1998 — 31.12.2019), 114 out of 629 males with H7_GLAUCSECINFLAM died.
Mortality risk
Mortality risk for people of age
years, who have H7_GLAUCSECINFLAM.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.159% | 0.192% |
| 5 | 0.754% | 1.124% |
| 10 | 1.798% | 2.812% |
| 15 | 3.606% | 5.501% |
| 20 | 6.519% | 9.447% |
Relationships between endpoints
↥Index endpoint: H7_GLAUCSECINFLAM – Glaucoma secondary to eye inflammation
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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