ocular hypertension: Abnormally high intraocular pressure.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
14068 |
4. Check minimum number of eventsNone |
14068 |
5. Include endpointsNone |
14068 |
6. Filter based on genotype QC (FinnGen only) |
13561 |
Control definitions (FinnGen only)
Extra metadata
Summary Statistics
↥-FinRegistry-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | |||
Whole population | 116607 | 73712 | 42352 |
Only index persons | 106382 | 67668 | 38714 |
Unadjusted period prevalence (%) | |||
Whole population | 1.77 | 2.11 | 1.18 |
Only index persons | 2.12 | 2.49 | 1.48 |
Median age at first event (years) | |||
Whole population | 65.41 | 65.92 | 64.57 |
Only index persons | 65.11 | 65.57 | 64.31 |
-FinnGen-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | 13561 | 8310 | 5251 |
Unadjusted period prevalence (%) | 3.02 | 3.26 | 2.64 |
Median age at first event (years) | 64.55 | 63.58 | 66.08 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H7_GLAUCSUSP and mortality.
Females
Parameter | HR [95% CI] | p-value |
---|---|---|
H7_GLAUCSUSP | 0.885 [0.81, 0.96] | 0.004 |
Birth year | 0.993 [0.98, 1.0] | 0.071 |
During the follow-up period (1.1.1998 — 31.12.2019), 9216 out of 55203 females with H7_GLAUCSUSP died.
Males
Parameter | HR [95% CI] | p-value |
---|---|---|
H7_GLAUCSUSP | 0.912 [0.83, 1.0] | 0.058 |
Birth year | 0.987 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 6277 out of 32273 males with H7_GLAUCSUSP died.
Mortality risk
Mortality risk for people of age
years, who have H7_GLAUCSUSP.N-year risk | Females | Males |
---|---|---|
1 | 0.079% | 0.157% |
5 | 0.477% | 1.024% |
10 | 1.123% | 2.475% |
15 | 2.312% | 4.865% |
20 | 3.797% | 8.204% |
Relationships between endpoints
↥Index endpoint: H7_GLAUCSUSP – Glaucoma suspect
GWS hits: 29