Glaucoma suspect

H7_GLAUCSUSP

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H40.0
  • Hospital discharge: ICD-9 3650
  • Hospital discharge: ICD-8 37597
  • Cause of death: ICD-10 H40.0
  • Cause of death: ICD-9 3650
  • Cause of death: ICD-8 37597

2 out of 7 registries used, show all original rules.

14068

4. Check minimum number of events

None

14068

5. Include endpoints

None

14068

6. Filter based on genotype QC (FinnGen only)

13561

Control definitions (FinnGen only)

Control exclude H7_GLAUCOMA

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H40
Name in latin Suspicio glaucomatis

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 116607 73712 42352
Only index persons 106382 67668 38714
Unadjusted period prevalence (%)
Whole population 1.77 2.11 1.18
Only index persons 2.12 2.49 1.48
Median age at first event (years)
Whole population 65.41 65.92 64.57
Only index persons 65.11 65.57 64.31

-FinnGen-

Key figures

All Female Male
Number of individuals 13561 8310 5251
Unadjusted period prevalence (%) 3.02 3.26 2.64
Median age at first event (years) 64.55 63.58 66.08

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint H7_GLAUCSUSP and mortality.

Females

Parameter HR [95% CI] p-value
H7_GLAUCSUSP 0.885 [0.81, 0.96] 0.004
Birth year 0.993 [0.98, 1.0] 0.071

During the follow-up period (1.1.1998 — 31.12.2019), 9216 out of 55203 females with H7_GLAUCSUSP died.

Males

Parameter HR [95% CI] p-value
H7_GLAUCSUSP 0.912 [0.83, 1.0] 0.058
Birth year 0.987 [0.98, 1.0] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 6277 out of 32273 males with H7_GLAUCSUSP died.

Mortality risk

Mortality risk for people of age

years, who have H7_GLAUCSUSP.

N-year risk Females Males
1 0.079% 0.157%
5 0.477% 1.024%
10 1.123% 2.475%
15 2.312% 4.865%
20 3.797% 8.204%

Relationships between endpoints

Index endpoint: H7_GLAUCSUSP – Glaucoma suspect

GWS hits: 29

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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