Primary open-angle glaucoma, strict

H7_GLAUCOMA_POAG

open-angle glaucoma: Chronic outflow obstruction of the eye's drainage canals that can lead to increased internal eye pressure and optic nerve damage.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H40.1
  • Hospital discharge: ICD-9 3651[A|C|E|X]
  • Hospital discharge: ICD-8 37510
  • Hospital discharge: excluded ICD-10 H40.10, H40.12
  • Cause of death: ICD-10 H40.1
  • Cause of death: ICD-9 3651[A|C|E|X]
  • Cause of death: ICD-8 37510
  • Cause of death: excluded ICD-10 H40.10, H40.12

2 out of 7 registries used, show all original rules.

9911

4. Check minimum number of events

None

9911

5. Include endpoints

None

9911

6. Filter based on genotype QC (FinnGen only)

9565

Control definitions (FinnGen only)

Control exclude H7_GLAUCOMA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF4
Parent code in ICD-10 H40
Name in latin Glaucoma simplex primarium

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 97098 58563 37736
Only index persons 79574 48741 30833
Unadjusted period prevalence (%)
Whole population 1.43 1.68 1.05
Only index persons 1.55 1.79 1.18
Median age at first event (years)
Whole population 71.03 71.96 69.63
Only index persons 70.76 71.66 69.33

-FinnGen-

Key figures

All Female Male
Number of individuals 9565 5280 4285
Unadjusted period prevalence (%) 2.11 2.07 2.15
Median age at first event (years) 69.58 69.23 70.01

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint H7_GLAUCOMA_POAG and mortality.

Females

Parameter HR [95% CI] p-value
H7_GLAUCOMA_POAG 0.931 [0.86, 1.0] 0.066
Birth year 0.995 [0.99, 1.0] 0.189

During the follow-up period (1.1.1998 — 31.12.2019), 12269 out of 40833 females with H7_GLAUCOMA_POAG died.

Males

Parameter HR [95% CI] p-value
H7_GLAUCOMA_POAG 0.979 [0.9, 1.07] 0.634
Birth year 0.99 [0.98, 1.0] 0.026

During the follow-up period (1.1.1998 — 31.12.2019), 8092 out of 26243 males with H7_GLAUCOMA_POAG died.

Mortality risk

Mortality risk for people of age

years, who have H7_GLAUCOMA_POAG.

N-year risk Females Males
1 0.078% 0.177%
5 0.52% 1.151%
10 1.36% 3.123%
15 2.46% 6.173%
20 4.383% 10.442%

Relationships between endpoints

Index endpoint: H7_GLAUCOMA_POAG – Primary open-angle glaucoma, strict

GWS hits: 48

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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