open-angle glaucoma: Chronic outflow obstruction of the eye's drainage canals that can lead to increased internal eye pressure and optic nerve damage.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
9911 |
4. Check minimum number of eventsNone |
9911 |
5. Include endpointsNone |
9911 |
6. Filter based on genotype QC (FinnGen only) |
9565 |
Control definitions (FinnGen only)
Extra metadata
Similar endpoints
↥List of similar endpoints to Primary open-angle glaucoma, strict based on the number of shared cases.
Similar with more cases:
- Primary open-angle glaucoma
- Glaucoma
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥Summary Statistics
↥-FinRegistry-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | |||
Whole population | 97098 | 58563 | 37736 |
Only index persons | 79574 | 48741 | 30833 |
Unadjusted period prevalence (%) | |||
Whole population | 1.43 | 1.68 | 1.05 |
Only index persons | 1.55 | 1.79 | 1.18 |
Median age at first event (years) | |||
Whole population | 71.03 | 71.96 | 69.63 |
Only index persons | 70.76 | 71.66 | 69.33 |
-FinnGen-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | 9565 | 5280 | 4285 |
Unadjusted period prevalence (%) | 2.11 | 2.07 | 2.15 |
Median age at first event (years) | 69.58 | 69.23 | 70.01 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H7_GLAUCOMA_POAG and mortality.
Females
Parameter | HR [95% CI] | p-value |
---|---|---|
H7_GLAUCOMA_POAG | 0.931 [0.86, 1.0] | 0.066 |
Birth year | 0.995 [0.99, 1.0] | 0.189 |
During the follow-up period (1.1.1998 — 31.12.2019), 12269 out of 40833 females with H7_GLAUCOMA_POAG died.
Males
Parameter | HR [95% CI] | p-value |
---|---|---|
H7_GLAUCOMA_POAG | 0.979 [0.9, 1.07] | 0.634 |
Birth year | 0.99 [0.98, 1.0] | 0.026 |
During the follow-up period (1.1.1998 — 31.12.2019), 8092 out of 26243 males with H7_GLAUCOMA_POAG died.
Mortality risk
Mortality risk for people of age
years, who have H7_GLAUCOMA_POAG.N-year risk | Females | Males |
---|---|---|
1 | 0.078% | 0.177% |
5 | 0.52% | 1.151% |
10 | 1.36% | 3.123% |
15 | 2.46% | 6.173% |
20 | 4.383% | 10.442% |
Relationships between endpoints
↥Index endpoint: H7_GLAUCOMA_POAG – Primary open-angle glaucoma, strict
GWS hits: 48