No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
2691 |
4. Check minimum number of eventsNone |
2691 |
5. Include endpointsNone |
2691 |
6. Filter based on genotype QC (FinnGen only) |
2595 |
Control definitions (FinnGen only)
Control exclude
H7_GLAUCOMA
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
H401
Name in latin
Glaucoma non hypertensivum [primarium/residuale]
Similar endpoints
↥List of similar endpoints to
Normotensive glaucoma
based on the number of shared cases.
Similar with more cases:
- Primary open-angle glaucoma, strict
- Primary open-angle glaucoma
- Glaucoma
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 19419 | 12986 | 6379 |
| Only index persons | 18134 | 12188 | 5946 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.31 | 0.37 | 0.18 |
| Only index persons | 0.38 | 0.45 | 0.23 |
| Median age at first event (years) | |||
| Whole population | 73.06 | 73.32 | 72.54 |
| Only index persons | 72.75 | 73.01 | 72.22 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2595 | 1661 | 934 |
| Unadjusted period prevalence (%) | 0.59 | 0.65 | 0.47 |
| Median age at first event (years) | 71.28 | 70.67 | 72.36 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H7_GLAUCOMA_NTG and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_GLAUCOMA_NTG | 0.892 [0.81, 0.98] | 0.022 |
| Birth year | 0.993 [0.99, 1.0] | 0.113 |
During the follow-up period (1.1.1998 — 31.12.2019), 2411 out of 10420 females with H7_GLAUCOMA_NTG died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_GLAUCOMA_NTG | 0.969 [0.85, 1.1] | 0.63 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 1393 out of 5088 males with H7_GLAUCOMA_NTG died.
Mortality risk
Mortality risk for people of age
years, who have H7_GLAUCOMA_NTG.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.051% | 0.175% |
| 5 | 0.396% | 1.106% |
| 10 | 1.104% | 2.751% |
| 15 | 2.302% | 5.426% |
| 20 | 4.091% | 8.938% |
Relationships between endpoints
↥Index endpoint: H7_GLAUCOMA_NTG – Normotensive glaucoma
GWS hits: 7
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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