glaucoma: Increased pressure in the eyeball due to obstruction of the outflow of aqueous humor.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
2287 |
4. Check minimum number of eventsNone |
2287 |
5. Include endpointsNone |
2287 |
6. Filter based on genotype QC (FinnGen only) |
2189 |
Control definitions (FinnGen only)
Extra metadata
Summary Statistics
↥-FinRegistry-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | |||
Whole population | 27050 | 16252 | 10529 |
Only index persons | 21210 | 13148 | 8062 |
Unadjusted period prevalence (%) | |||
Whole population | 0.40 | 0.47 | 0.29 |
Only index persons | 0.42 | 0.48 | 0.31 |
Median age at first event (years) | |||
Whole population | 73.83 | 76.31 | 70.15 |
Only index persons | 74.25 | 76.75 | 70.16 |
-FinnGen-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | 2189 | 1212 | 977 |
Unadjusted period prevalence (%) | 0.48 | 0.48 | 0.49 |
Median age at first event (years) | 70.66 | 71.16 | 70.05 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H7_GLAUCNAS and mortality.
Females
Parameter | HR [95% CI] | p-value |
---|---|---|
H7_GLAUCNAS | 1.308 [1.16, 1.47] | < 0.001 |
Birth year | 0.991 [0.98, 1.0] | 0.037 |
During the follow-up period (1.1.1998 — 31.12.2019), 3872 out of 10572 females with H7_GLAUCNAS died.
Males
Parameter | HR [95% CI] | p-value |
---|---|---|
H7_GLAUCNAS | 1.303 [1.12, 1.52] | < 0.001 |
Birth year | 0.987 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 2175 out of 6187 males with H7_GLAUCNAS died.
Mortality risk
Mortality risk for people of age
years, who have H7_GLAUCNAS.N-year risk | Females | Males |
---|---|---|
1 | 0.136% | 0.221% |
5 | 0.748% | 1.452% |
10 | 1.749% | 3.565% |
15 | 3.474% | 6.833% |
20 | 5.94% | 11.611% |
Relationships between endpoints
↥Index endpoint: H7_GLAUCNAS – Other and unspecified glaucoma
GWS hits: 4