Other and unspecified glaucoma

H7_GLAUCNAS

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H40.8, H40.9
  • Hospital discharge: ICD-9 3656X|3656C|365[8-9]
  • Hospital discharge: ICD-8 3752|3759
  • Hospital discharge: excluded ICD-8 37597
  • Cause of death: ICD-10 H40.8, H40.9
  • Cause of death: ICD-9 3656X|3656C|365[8-9]
  • Cause of death: ICD-8 3752|3759
  • Cause of death: excluded ICD-8 37597

2 out of 7 registries used, show all original rules.

2287

4. Check minimum number of events

None

2287

5. Include endpoints

None

2287

6. Filter based on genotype QC (FinnGen only)

2189

Control definitions (FinnGen only)

Control exclude H7_GLAUCOMA

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 27050 16252 10529
Only index persons 21210 13148 8062
Unadjusted period prevalence (%)
Whole population 0.40 0.47 0.29
Only index persons 0.42 0.48 0.31
Median age at first event (years)
Whole population 73.83 76.31 70.15
Only index persons 74.25 76.75 70.16

-FinnGen-

Key figures

All Female Male
Number of individuals 2189 1212 977
Unadjusted period prevalence (%) 0.48 0.48 0.49
Median age at first event (years) 70.66 71.16 70.05

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint H7_GLAUCNAS and mortality.

Females

Parameter HR [95% CI] p-value
H7_GLAUCNAS 1.308 [1.16, 1.47] < 0.001
Birth year 0.991 [0.98, 1.0] 0.037

During the follow-up period (1.1.1998 — 31.12.2019), 3872 out of 10572 females with H7_GLAUCNAS died.

Males

Parameter HR [95% CI] p-value
H7_GLAUCNAS 1.303 [1.12, 1.52] < 0.001
Birth year 0.987 [0.98, 1.0] 0.005

During the follow-up period (1.1.1998 — 31.12.2019), 2175 out of 6187 males with H7_GLAUCNAS died.

Mortality risk

Mortality risk for people of age

years, who have H7_GLAUCNAS.

N-year risk Females Males
1 0.136% 0.221%
5 0.748% 1.452%
10 1.749% 3.565%
15 3.474% 6.833%
20 5.94% 11.611%

Relationships between endpoints

Index endpoint: H7_GLAUCNAS – Other and unspecified glaucoma

GWS hits: 4

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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