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Glaucoma, exfoliation

DOID EFO Endpoint Browser PheWeb

H7_GLAUCOMA_XFG

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H40.10
  • Hospital discharge: ICD-9 — 3651B
  • Hospital discharge: ICD-8 — 37512
  • Cause of death: ICD-10 — H40.10
  • Cause of death: ICD-9 — 3651B
  • Cause of death: ICD-8 — 37512

2 out of 7 registries used, show all original rules.

3962

4. Check minimum number of events

None

3962

5. Include endpoints

None

3962

6. Filter based on genotype QC (FinnGen only)

3777

Control definitions (FinnGen only)

Control exclude H7_GLAUCOMA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF4
Parent code in ICD-10 H401
Name in latin Glaucoma capsulare [primarium/residuale] cum syndromate exfoliationis

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 50095 32712 16908
Only index persons 38107 25566 12541
Unadjusted period prevalence (%)
Whole population 0.78 0.94 0.47
Only index persons 0.79 0.94 0.48
Median age at first event (years)
Whole population 74.18 74.76 73.11
Only index persons 73.97 74.56 72.78

-FinnGen-

Key figures

All Female Male
Number of individuals 3777 2106 1671
Unadjusted period prevalence (%) 0.83 0.83 0.84
Median age at first event (years) 72.33 72.00 72.75

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint H7_GLAUCOMA_XFG and mortality.

Females

Parameter HR [95% CI] p-value
H7_GLAUCOMA_XFG 0.876 [0.82, 0.94] < 0.001
Birth year 0.994 [0.99, 1.0] 0.178

During the follow-up period (1.1.1998 — 31.12.2019), 9065 out of 22936 females with H7_GLAUCOMA_XFG died.

Males

Parameter HR [95% CI] p-value
H7_GLAUCOMA_XFG 0.91 [0.84, 0.99] 0.032
Birth year 0.985 [0.98, 0.99] 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 4878 out of 11833 males with H7_GLAUCOMA_XFG died.

Mortality risk

Mortality risk for people of age

years, who have H7_GLAUCOMA_XFG.

N-year risk Females Males
1 0.071% 0.185%
5 0.498% 0.955%
10 1.294% 2.41%
15 2.583% 4.733%
20 4.311% 7.942%

Relationships between endpoints

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Index endpoint: H7_GLAUCOMA_XFG – Glaucoma, exfoliation

GWS hits: 10

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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