age-related macular degeneration: Age-related loss of vision in the central portion of the retina (macula), secondary to retinal degeneration.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditions
|
473579 |
3. Check pre-conditions, main-only, mode, registry filtersPre-conditions: EVENT_AGE>=50 Registry filters:
2 out of 7 registries used, show all original rules. |
6093 |
4. Check minimum number of eventsNone |
6093 |
5. Include endpointsNone |
6093 |
6. Filter based on genotype QC (FinnGen only) |
5890 |
Control definitions (FinnGen only)
Control exclude
H7_RETINOPATHYDIAB, H7_RETINASEPAR, MACULA_NAS, H7_GLAUCPRIMOPEN, H7_GLAUCCLOSEPRIM, H7_GLAUCSECTRAUMA, H7_GLAUCSECINFLAM, H7_GLAUCSECDISEASE, H7_GLAUCSECDRUG, H7_GLAUCNAS
Control pre-conditions
DEATH_AGE>=50
Control conditions
not WET_AMD_EARLY
Extra metadata
Level in the ICD hierarchy
5
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H35
Name in latin
Degeneratio maculae senilis exsudativa
Similar endpoints
↥List of similar endpoints to
Wet age-related macular degeneration
based on the number of shared cases.
Similar with more cases:
- Age-related macular degeneration (whether dry or wet)
- Degeneration of macula and posterior pole
- Other retinal disorders
- Disorders of choroid and retina
- Diseases of the eye and adnexa
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 55712 | 35752 | 19781 |
| Only index persons | 52323 | 33890 | 18433 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.85 | 1.02 | 0.55 |
| Only index persons | 1.05 | 1.25 | 0.70 |
| Median age at first event (years) | |||
| Whole population | 79.09 | 80.01 | 77.43 |
| Only index persons | 79.02 | 79.96 | 77.30 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 5890 | 3040 | 2850 |
| Unadjusted period prevalence (%) | 1.31 | 1.19 | 1.43 |
| Median age at first event (years) | 76.64 | 76.91 | 76.36 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint WET_AMD and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| WET_AMD | 0.833 [0.76, 0.91] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.306 |
During the follow-up period (1.1.1998 — 31.12.2019), 11318 out of 30853 females with WET_AMD died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| WET_AMD | 0.905 [0.81, 1.01] | 0.064 |
| Birth year | 0.987 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 6694 out of 16881 males with WET_AMD died.
Mortality risk
Mortality risk for people of age
years, who have WET_AMD.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.084% | 0.179% |
| 5 | 0.505% | 0.921% |
| 10 | 1.256% | 2.546% |
| 15 | 2.328% | 4.81% |
| 20 | 4.171% | 8.311% |
Relationships between endpoints
↥Index endpoint: WET_AMD – Wet age-related macular degeneration
GWS hits: 22
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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