pars planitis: Form of granulomatous uveitis occurring in the region of the pars plana. This disorder is a common condition with no detectable focal pathology. It causes fibrovascular proliferation at the inferior ora serrata.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
957 |
4. Check minimum number of eventsNone |
957 |
5. Include endpointsNone |
957 |
6. Filter based on genotype QC (FinnGen only) |
927 |
Control definitions (FinnGen only)
Control exclude
H7_CHOROIDRETINA
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF6
Similar endpoints
↥List of similar endpoints to
Chorioretinal inflammation
based on the number of shared cases.
Similar with more cases:
- Disorders of choroid and retina
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 7447 | 4043 | 3349 |
| Only index persons | 6715 | 3705 | 3010 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.11 | 0.12 | 0.09 |
| Only index persons | 0.13 | 0.14 | 0.11 |
| Median age at first event (years) | |||
| Whole population | 44.36 | 45.40 | 43.18 |
| Only index persons | 43.01 | 43.90 | 41.91 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 927 | 545 | 382 |
| Unadjusted period prevalence (%) | 0.20 | 0.21 | 0.19 |
| Median age at first event (years) | 45.18 | 41.88 | 49.88 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H7_CHORIORETINFLAM and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CHORIORETINFLAM | 1.329 [1.13, 1.57] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.086 |
During the follow-up period (1.1.1998 — 31.12.2019), 402 out of 2634 females with H7_CHORIORETINFLAM died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CHORIORETINFLAM | 1.492 [1.26, 1.77] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 397 out of 2150 males with H7_CHORIORETINFLAM died.
Mortality risk
Mortality risk for people of age
years, who have H7_CHORIORETINFLAM.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.139% | 0.289% |
| 5 | 0.664% | 1.79% |
| 10 | 1.88% | 4.127% |
| 15 | 3.62% | 7.326% |
| 20 | 6.451% | 12.661% |
Relationships between endpoints
↥Index endpoint: H7_CHORIORETINFLAM – Chorioretinal inflammation
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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