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Retinal haemorrhage

DOID EFO Endpoint Browser PheWeb

H7_RETINAHAEMORR

age-related macular degeneration: Age-related loss of vision in the central portion of the retina (macula), secondary to retinal degeneration.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H35.6
  • Hospital discharge: ICD-9 — 3628A
  • Hospital discharge: ICD-8 — 37701
  • Cause of death: ICD-10 — H35.6
  • Cause of death: ICD-9 — 3628A
  • Cause of death: ICD-8 — 37701

2 out of 7 registries used, show all original rules.

743

4. Check minimum number of events

None

743

5. Include endpoints

None

743

6. Filter based on genotype QC (FinnGen only)

712

Control definitions (FinnGen only)

Control exclude H7_CHOROIDRETINA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H35
Name in latin Haemorrhagia retinae

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 6470 3761 2664
Only index persons 5746 3425 2321
Unadjusted period prevalence (%)
Whole population 0.09 0.11 0.07
Only index persons 0.11 0.13 0.09
Median age at first event (years)
Whole population 71.27 74.94 66.17
Only index persons 71.43 75.09 66.04

-FinnGen-

Key figures

All Female Male
Number of individuals 712 369 343
Unadjusted period prevalence (%) 0.16 0.14 0.17
Median age at first event (years) 68.27 68.11 68.45

-FinRegistry-

Age distribution of first events

01020304050607080900.0k0.2k0.4k0.6k0.8k1.0k1.2k1.4kAgeIndividuals

-FinnGen-

Age distribution of first events

0102030405060708090020406080100120140160180AgeIndividuals

-FinRegistry-

Year distribution of first events

197519801985199019952000200520102015202020220.0k0.2k0.4k0.6k0.8k1.0k1.2k1.4k1.6kYearIndividuals

-FinnGen-

Year distribution of first events

197019851990200020052010201520202023020406080100120140160180YearIndividuals

-FinRegistry-

Cumulative Incidence Function

01020304050607080901000.00.10.20.30.40.50.60.70.80.91.0AgeProbability of first incidence (%)

-FinnGen-

Cumulative Incidence Function

01020304050607080901000.00.10.20.30.40.50.60.70.80.91.0AgeProbability of first incidence (%)

Mortality – FinRegistry

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Association

Association between endpoint H7_RETINAHAEMORR and mortality.

Females

Parameter HR [95% CI] p-value
H7_RETINAHAEMORR 0.987 [0.87, 1.12] 0.838
Birth year 0.998 [0.99, 1.01] 0.6

During the follow-up period (1.1.1998 — 31.12.2019), 1022 out of 3021 females with H7_RETINAHAEMORR died.

Males

Parameter HR [95% CI] p-value
H7_RETINAHAEMORR 1.254 [1.05, 1.49] 0.011
Birth year 0.983 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 664 out of 2055 males with H7_RETINAHAEMORR died.

Mortality risk

Mortality risk for people of age

years, who have H7_RETINAHAEMORR.

N-year risk Females Males
1 0.073% 0.242%
5 0.625% 1.341%
10 1.745% 3.327%
15 3.176% 6.081%
20 5.491% 10.27%

Relationships between endpoints

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Index endpoint: H7_RETINAHAEMORR – Retinal haemorrhage

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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