age-related macular degeneration: Age-related loss of vision in the central portion of the retina (macula), secondary to retinal degeneration.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
743 |
4. Check minimum number of eventsNone |
743 |
5. Include endpointsNone |
743 |
6. Filter based on genotype QC (FinnGen only) |
712 |
Control definitions (FinnGen only)
Control exclude
H7_CHOROIDRETINA
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H35
Name in latin
Haemorrhagia retinae
Similar endpoints
↥List of similar endpoints to
Retinal haemorrhage
based on the number of shared cases.
Similar with more cases:
- Other retinal disorders
- Disorders of choroid and retina
- Bleeding
- Diseases of the eye and adnexa
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 6470 | 3761 | 2664 |
| Only index persons | 5746 | 3425 | 2321 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.09 | 0.11 | 0.07 |
| Only index persons | 0.11 | 0.13 | 0.09 |
| Median age at first event (years) | |||
| Whole population | 71.27 | 74.94 | 66.17 |
| Only index persons | 71.43 | 75.09 | 66.04 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 712 | 369 | 343 |
| Unadjusted period prevalence (%) | 0.16 | 0.14 | 0.17 |
| Median age at first event (years) | 68.27 | 68.11 | 68.45 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H7_RETINAHAEMORR and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_RETINAHAEMORR | 0.987 [0.87, 1.12] | 0.838 |
| Birth year | 0.998 [0.99, 1.01] | 0.6 |
During the follow-up period (1.1.1998 — 31.12.2019), 1022 out of 3021 females with H7_RETINAHAEMORR died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_RETINAHAEMORR | 1.254 [1.05, 1.49] | 0.011 |
| Birth year | 0.983 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 664 out of 2055 males with H7_RETINAHAEMORR died.
Mortality risk
Mortality risk for people of age
years, who have H7_RETINAHAEMORR.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.073% | 0.242% |
| 5 | 0.625% | 1.341% |
| 10 | 1.745% | 3.327% |
| 15 | 3.176% | 6.081% |
| 20 | 5.491% | 10.27% |
Relationships between endpoints
↥Index endpoint: H7_RETINAHAEMORR – Retinal haemorrhage
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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