age-related macular degeneration: Age-related loss of vision in the central portion of the retina (macula), secondary to retinal degeneration.
Background retinopathy and retinal vascular changes
DOID EFO Endpoint Browser PheWeb
H7_BCKRNDRETINOPAT
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
688 |
4. Check minimum number of eventsNone |
688 |
5. Include endpointsNone |
688 |
6. Filter based on genotype QC (FinnGen only) |
658 |
Control definitions (FinnGen only)
Control exclude
H7_CHOROIDRETINA
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF6
Parent code in ICD-10
H35
Name in latin
Retinopathia recessualis et commutationes vasculares retinae
Similar endpoints
↥List of similar endpoints to
Background retinopathy and retinal vascular changes
based on the number of shared cases.
Similar with more cases:
- Other retinal disorders
- Disorders of choroid and retina
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 6024 | 2953 | 3018 |
| Only index persons | 5178 | 2570 | 2608 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.08 | 0.08 | 0.08 |
| Only index persons | 0.10 | 0.09 | 0.10 |
| Median age at first event (years) | |||
| Whole population | 59.07 | 63.57 | 54.72 |
| Only index persons | 58.11 | 62.71 | 53.57 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 658 | 318 | 340 |
| Unadjusted period prevalence (%) | 0.15 | 0.12 | 0.17 |
| Median age at first event (years) | 57.34 | 57.35 | 57.32 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H7_BCKRNDRETINOPAT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_BCKRNDRETINOPAT | 1.398 [1.23, 1.59] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.678 |
During the follow-up period (1.1.1998 — 31.12.2019), 810 out of 2446 females with H7_BCKRNDRETINOPAT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_BCKRNDRETINOPAT | 1.353 [1.17, 1.56] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.037 |
During the follow-up period (1.1.1998 — 31.12.2019), 716 out of 2418 males with H7_BCKRNDRETINOPAT died.
Mortality risk
Mortality risk for people of age
years, who have H7_BCKRNDRETINOPAT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.149% | 0.271% |
| 5 | 0.836% | 1.616% |
| 10 | 2.152% | 4.152% |
| 15 | 4.438% | 7.965% |
| 20 | 7.889% | 13.748% |
Relationships between endpoints
↥Index endpoint: H7_BCKRNDRETINOPAT – Background retinopathy and retinal vascular changes
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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