macular degeneration: Loss of vision in the central portion of the retina (macula), secondary to retinal degeneration. [ NCIT:P378 ]
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
144 |
4. Check minimum number of eventsNone |
144 |
5. Include endpointsNone |
144 |
6. Filter based on genotype QC (FinnGen only) |
140 |
Control definitions (FinnGen only)
Control exclude
H7_CHOROIDRETINA
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Other proliferative retinopathy
based on the number of shared cases.
Similar with more cases:
- Other retinal disorders
- Disorders of choroid and retina
- Diseases of the eye and adnexa
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1077 | 486 | 586 |
| Only index persons | 954 | 436 | 518 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.01 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 57.82 | 60.71 | 55.52 |
| Only index persons | 57.13 | 59.71 | 54.95 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 140 | 65 | 75 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.04 |
| Median age at first event (years) | 51.91 | 49.38 | 54.10 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint H7_PROLIFRETINOPATHOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_PROLIFRETINOPATHOTH | 1.757 [1.36, 2.28] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.222 |
During the follow-up period (1.1.1998 — 31.12.2019), 134 out of 421 females with H7_PROLIFRETINOPATHOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_PROLIFRETINOPATHOTH | 1.773 [1.38, 2.27] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 161 out of 508 males with H7_PROLIFRETINOPATHOTH died.
Mortality risk
Mortality risk for people of age
years, who have H7_PROLIFRETINOPATHOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.143% | 0.26% |
| 5 | 0.924% | 1.798% |
| 10 | 2.162% | 4.647% |
| 15 | 4.478% | 9.113% |
| 20 | 8.041% | 15.572% |
Relationships between endpoints
↥Index endpoint: H7_PROLIFRETINOPATHOTH – Other proliferative retinopathy
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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