No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1039 |
4. Check minimum number of eventsNone |
1039 |
5. Include endpointsNone |
1039 |
6. Filter based on genotype QC (FinnGen only) |
999 |
Control definitions (FinnGen only)
Control exclude
H7_CHOROIDRETINA
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H35
Name in latin
Degeneratio peripherica retinae
Similar endpoints
↥List of similar endpoints to
Peripheral retinal degeneration
based on the number of shared cases.
Similar with more cases:
- Other retinal disorders
- Disorders of choroid and retina
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 8552 | 5217 | 3289 |
| Only index persons | 7974 | 4943 | 3031 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.13 | 0.15 | 0.09 |
| Only index persons | 0.16 | 0.18 | 0.12 |
| Median age at first event (years) | |||
| Whole population | 54.77 | 54.91 | 54.52 |
| Only index persons | 53.95 | 54.19 | 53.57 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 999 | 620 | 379 |
| Unadjusted period prevalence (%) | 0.22 | 0.24 | 0.19 |
| Median age at first event (years) | 53.46 | 51.66 | 56.40 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H7_PERIPHRETINADEGEN and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_PERIPHRETINADEGEN | 0.789 [0.7, 0.88] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.27 |
During the follow-up period (1.1.1998 — 31.12.2019), 516 out of 4493 females with H7_PERIPHRETINADEGEN died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_PERIPHRETINADEGEN | 0.794 [0.7, 0.9] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.008 |
During the follow-up period (1.1.1998 — 31.12.2019), 436 out of 2702 males with H7_PERIPHRETINADEGEN died.
Mortality risk
Mortality risk for people of age
years, who have H7_PERIPHRETINADEGEN.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.07% | 0.126% |
| 5 | 0.405% | 0.914% |
| 10 | 1.083% | 2.273% |
| 15 | 2.237% | 4.398% |
| 20 | 4.093% | 7.697% |
Relationships between endpoints
↥Index endpoint: H7_PERIPHRETINADEGEN – Peripheral retinal degeneration
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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