retinopathy: Any disease or disorder of the retina.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1077 |
4. Check minimum number of eventsNone |
1077 |
5. Include endpointsNone |
1077 |
6. Filter based on genotype QC (FinnGen only) |
1045 |
Control definitions (FinnGen only)
Control exclude
H7_CHOROIDRETINA
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Other specified and unspecified retinal disorders
based on the number of shared cases.
Similar with more cases:
- Other retinal disorders
- Disorders of choroid and retina
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 8708 | 4643 | 4018 |
| Only index persons | 8147 | 4406 | 3741 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.12 | 0.13 | 0.11 |
| Only index persons | 0.15 | 0.16 | 0.14 |
| Median age at first event (years) | |||
| Whole population | 63.59 | 66.40 | 60.51 |
| Only index persons | 63.65 | 66.36 | 60.46 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1045 | 566 | 479 |
| Unadjusted period prevalence (%) | 0.23 | 0.22 | 0.24 |
| Median age at first event (years) | 63.61 | 63.41 | 63.86 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H7_RETINANAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_RETINANAS | 0.998 [0.87, 1.15] | 0.977 |
| Birth year | 0.996 [0.99, 1.0] | 0.289 |
During the follow-up period (1.1.1998 — 31.12.2019), 685 out of 3642 females with H7_RETINANAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_RETINANAS | 1.067 [0.91, 1.25] | 0.416 |
| Birth year | 0.988 [0.98, 1.0] | 0.015 |
During the follow-up period (1.1.1998 — 31.12.2019), 601 out of 3031 males with H7_RETINANAS died.
Mortality risk
Mortality risk for people of age
years, who have H7_RETINANAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.1% | 0.25% |
| 5 | 0.647% | 1.275% |
| 10 | 1.654% | 3.094% |
| 15 | 3.085% | 6.093% |
| 20 | 5.306% | 10.422% |
Relationships between endpoints
↥Index endpoint: H7_RETINANAS – Other specified and unspecified retinal disorders
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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