Tendinopathy: Disorders that are causes by overuse of tendons.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
23068 |
4. Check minimum number of eventsNone |
23068 |
5. Include endpoints |
26612 |
6. Filter based on genotype QC (FinnGen only) |
25653 |
Control definitions (FinnGen only)
Control exclude
M13_SOFTTISSUE
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Disorders of synovium and tendon
based on the number of shared cases.
Similar with more cases:
- Soft tissue disorders
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 198891 | 119147 | 78990 |
| Only index persons | 188422 | 114355 | 74067 |
| Unadjusted period prevalence (%) | |||
| Whole population | 2.92 | 3.41 | 2.21 |
| Only index persons | 3.66 | 4.20 | 2.83 |
| Median age at first event (years) | |||
| Whole population | 46.78 | 48.77 | 43.78 |
| Only index persons | 46.60 | 48.56 | 43.58 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 25653 | 17052 | 8601 |
| Unadjusted period prevalence (%) | 5.90 | 6.70 | 4.32 |
| Median age at first event (years) | 49.83 | 49.13 | 51.21 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_SYNOTEND and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_SYNOTEND | 0.843 [0.77, 0.92] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.532 |
During the follow-up period (1.1.1998 — 31.12.2019), 5956 out of 86612 females with M13_SYNOTEND died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_SYNOTEND | 0.882 [0.81, 0.96] | 0.006 |
| Birth year | 0.984 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 5052 out of 55611 males with M13_SYNOTEND died.
Mortality risk
Mortality risk for people of age
years, who have M13_SYNOTEND.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.066% | 0.127% |
| 5 | 0.523% | 0.845% |
| 10 | 1.286% | 2.276% |
| 15 | 2.641% | 4.324% |
| 20 | 4.673% | 7.397% |
Relationships between endpoints
↥Index endpoint: M13_SYNOTEND – Disorders of synovium and tendon
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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