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Other/unspecified synovitis and tenosynovitis

DOID EFO Endpoint Browser PheWeb

M13_TENDOSYNOVITISNAS

Tenosynovitis: Inflammation of the synovial lining of a tendon sheath. Causes include trauma, tendon stress, bacterial disease (gonorrhea, tuberculosis), rheumatic disease, and gout. Common sites are the hand, wrist, shoulder capsule, hip capsule, hamstring muscles, and Achilles tendon. The tendon sheaths become inflamed and painful, and accumulate fluid. Joint mobility is usually reduced.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — M65.8, M65.9
  • Hospital discharge: ICD-9 — 7270
  • Hospital discharge: ICD-8 — 7310[0-3]
  • Hospital discharge: excluded ICD-9 — 7270A
  • Cause of death: ICD-10 — M65.8, M65.9
  • Cause of death: ICD-9 — 7270
  • Cause of death: ICD-8 — 7310[0-3]
  • Cause of death: excluded ICD-9 — 7270A

2 out of 7 registries used, show all original rules.

4666

4. Check minimum number of events

None

4666

5. Include endpoints

None

4666

6. Filter based on genotype QC (FinnGen only)

4504

Control definitions (FinnGen only)

Control exclude M13_SOFTTISSUE

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF4

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 37510 21518 15773
Only index persons 33909 19696 14213
Unadjusted period prevalence (%)
Whole population 0.54 0.62 0.44
Only index persons 0.65 0.72 0.54
Median age at first event (years)
Whole population 42.18 46.23 36.55
Only index persons 40.96 45.10 35.22

-FinnGen-

Key figures

All Female Male
Number of individuals 4504 2850 1654
Unadjusted period prevalence (%) 1.01 1.12 0.83
Median age at first event (years) 43.85 44.44 42.84

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint M13_TENDOSYNOVITISNAS and mortality.

Females

Parameter HR [95% CI] p-value
M13_TENDOSYNOVITISNAS 0.913 [0.81, 1.03] 0.127
Birth year 0.996 [0.99, 1.0] 0.364

During the follow-up period (1.1.1998 — 31.12.2019), 755 out of 10760 females with M13_TENDOSYNOVITISNAS died.

Males

Parameter HR [95% CI] p-value
M13_TENDOSYNOVITISNAS 0.959 [0.84, 1.09] 0.516
Birth year 0.985 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 608 out of 7239 males with M13_TENDOSYNOVITISNAS died.

Mortality risk

Mortality risk for people of age

years, who have M13_TENDOSYNOVITISNAS.

N-year risk Females Males
1 0.105% 0.162%
5 0.553% 1.014%
10 1.468% 2.553%
15 2.794% 4.869%
20 5.04% 8.438%

Relationships between endpoints

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Index endpoint: M13_TENDOSYNOVITISNAS – Other/unspecified synovitis and tenosynovitis

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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