No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
343 |
4. Check minimum number of eventsNone |
343 |
5. Include endpointsNone |
343 |
6. Filter based on genotype QC (FinnGen only) |
333 |
Control definitions (FinnGen only)
Control exclude
M13_SOFTTISSUE
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M67
Name in latin
Hypertrophia membranae synovialis non alibi classificata
Similar endpoints
↥List of similar endpoints to
Synovial hypertrophy, not elsewhere classified
based on the number of shared cases.
Similar with more cases:
- Disorders of synovium and tendon
- Soft tissue disorders
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3056 | 1552 | 1498 |
| Only index persons | 3008 | 1538 | 1470 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.04 |
| Only index persons | 0.06 | 0.06 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 36.05 | 35.31 | 36.81 |
| Only index persons | 36.00 | 35.29 | 36.74 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 333 | 195 | 138 |
| Unadjusted period prevalence (%) | 0.07 | 0.08 | 0.07 |
| Median age at first event (years) | 39.30 | 37.55 | 41.78 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint M13_SYNOHYPERTROPH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_SYNOHYPERTROPH | 0.855 [0.66, 1.11] | 0.242 |
| Birth year | 0.99 [0.98, 1.0] | 0.031 |
During the follow-up period (1.1.1998 — 31.12.2019), 52 out of 1348 females with M13_SYNOHYPERTROPH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_SYNOHYPERTROPH | 0.647 [0.51, 0.83] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.015 |
During the follow-up period (1.1.1998 — 31.12.2019), 65 out of 1281 males with M13_SYNOHYPERTROPH died.
Mortality risk
Mortality risk for people of age
years, who have M13_SYNOHYPERTROPH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.068% | 0.126% |
| 5 | 0.399% | 0.722% |
| 10 | 0.962% | 1.892% |
| 15 | 1.923% | 3.781% |
| 20 | 3.398% | 6.383% |
Relationships between endpoints
↥Index endpoint: M13_SYNOHYPERTROPH – Synovial hypertrophy, not elsewhere classified
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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