synovitis: ['Inflammation of the SYNOVIAL MEMBRANE [ MeSH ]']
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
286 |
4. Check minimum number of eventsNone |
286 |
5. Include endpointsNone |
286 |
6. Filter based on genotype QC (FinnGen only) |
273 |
Control definitions (FinnGen only)
Control exclude
M13_SOFTTISSUE
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M67
Name in latin
Synovitis transitoria
Similar endpoints
↥List of similar endpoints to
Transient synovitis
based on the number of shared cases.
Similar with more cases:
- Disorders of synovium and tendon
- Soft tissue disorders
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4739 | 1722 | 3013 |
| Only index persons | 3886 | 1464 | 2422 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.07 | 0.05 | 0.08 |
| Only index persons | 0.08 | 0.05 | 0.09 |
| Median age at first event (years) | |||
| Whole population | 6.89 | 8.17 | 6.11 |
| Only index persons | 8.02 | 10.50 | 6.51 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 273 | 162 | 111 |
| Unadjusted period prevalence (%) | 0.06 | 0.06 | 0.06 |
| Median age at first event (years) | 27.44 | 32.63 | 19.88 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint M13_TRANSSYNOVITIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_TRANSSYNOVITIS | 1.188 [0.89, 1.59] | 0.244 |
| Birth year | 0.993 [0.98, 1.0] | 0.098 |
During the follow-up period (1.1.1998 — 31.12.2019), 53 out of 1551 females with M13_TRANSSYNOVITIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_TRANSSYNOVITIS | 1.195 [0.91, 1.56] | 0.196 |
| Birth year | 0.989 [0.98, 1.0] | 0.024 |
During the follow-up period (1.1.1998 — 31.12.2019), 71 out of 2694 males with M13_TRANSSYNOVITIS died.
Mortality risk
Mortality risk for people of age
years, who have M13_TRANSSYNOVITIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.096% | 0.247% |
| 5 | 0.579% | 1.482% |
| 10 | 1.456% | 3.667% |
| 15 | 2.989% | 7.022% |
| 20 | 5.127% | 11.837% |
Relationships between endpoints
↥Index endpoint: M13_TRANSSYNOVITIS – Transient synovitis
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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