auditory system disease: Pathological processes of the ear, the hearing, and the equilibrium system of the body.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
57571 |
4. Check minimum number of eventsNone |
57571 |
5. Include endpoints |
57986 |
6. Filter based on genotype QC (FinnGen only) |
55868 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Other disorders of ear
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 505440 | 262536 | 240321 |
| Only index persons | 456161 | 241088 | 215073 |
| Unadjusted period prevalence (%) | |||
| Whole population | 7.11 | 7.52 | 6.71 |
| Only index persons | 8.56 | 8.86 | 8.21 |
| Median age at first event (years) | |||
| Whole population | 65.71 | 66.78 | 64.48 |
| Only index persons | 65.06 | 66.13 | 63.85 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 55868 | 28259 | 27609 |
| Unadjusted period prevalence (%) | 12.47 | 11.10 | 13.87 |
| Median age at first event (years) | 63.86 | 61.13 | 66.65 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H8_OTHEREAR and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_OTHEREAR | 0.889 [0.82, 0.96] | 0.003 |
| Birth year | 0.995 [0.99, 1.0] | 0.139 |
During the follow-up period (1.1.1998 — 31.12.2019), 59462 out of 230985 females with H8_OTHEREAR died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_OTHEREAR | 0.93 [0.86, 1.01] | 0.071 |
| Birth year | 0.99 [0.98, 1.0] | 0.012 |
During the follow-up period (1.1.1998 — 31.12.2019), 56717 out of 209143 males with H8_OTHEREAR died.
Mortality risk
Mortality risk for people of age
years, who have H8_OTHEREAR.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.074% | 0.17% |
| 5 | 0.443% | 1.076% |
| 10 | 1.224% | 2.734% |
| 15 | 2.276% | 5.11% |
| 20 | 4.055% | 8.877% |
Relationships between endpoints
↥Index endpoint: H8_OTHEREAR – Other disorders of ear
GWS hits: 23
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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