No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
11380 |
6. Filter based on genotype QC (FinnGen only) |
10961 |
Control definitions (FinnGen only)
Control exclude
H8_OTHEREAR
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Other hearing loss
based on the number of shared cases.
Similar with more cases:
- Other disorders of ear
- Diseases of the ear and mastoid process
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 115989 | 63773 | 51567 |
| Only index persons | 102436 | 57358 | 45078 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.65 | 1.83 | 1.44 |
| Only index persons | 1.94 | 2.11 | 1.72 |
| Median age at first event (years) | |||
| Whole population | 74.93 | 76.81 | 72.59 |
| Only index persons | 74.27 | 76.10 | 71.94 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 10961 | 5323 | 5638 |
| Unadjusted period prevalence (%) | 2.47 | 2.09 | 2.83 |
| Median age at first event (years) | 69.93 | 68.08 | 71.68 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H8_OTHHEARINGLOSS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_OTHHEARINGLOSS | 0.949 [0.87, 1.03] | 0.222 |
| Birth year | 1.0 [0.99, 1.01] | 0.924 |
During the follow-up period (1.1.1998 — 31.12.2019), 21397 out of 54019 females with H8_OTHHEARINGLOSS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_OTHHEARINGLOSS | 0.956 [0.87, 1.05] | 0.37 |
| Birth year | 0.986 [0.98, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 16050 out of 41752 males with H8_OTHHEARINGLOSS died.
Mortality risk
Mortality risk for people of age
years, who have H8_OTHHEARINGLOSS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.09% | 0.231% |
| 5 | 0.529% | 1.13% |
| 10 | 1.385% | 2.683% |
| 15 | 2.951% | 5.064% |
| 20 | 5.432% | 8.299% |
Relationships between endpoints
↥Index endpoint: H8_OTHHEARINGLOSS – Other hearing loss
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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