sensorineural hearing loss: Hearing loss in which the root cause lies in the inner ear or sensory organ (cochlea and associated structures) or the vestibulocochlear nerve (cranial nerve VIII).
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
2827 |
4. Check minimum number of eventsNone |
2827 |
5. Include endpointsNone |
2827 |
6. Filter based on genotype QC (FinnGen only) |
2720 |
Control definitions (FinnGen only)
Control exclude
H8_OTHEREAR
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Other specified/unspecified hearing loss
based on the number of shared cases.
Similar with more cases:
- Other hearing loss
- Other disorders of ear
- Diseases of the ear and mastoid process
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 30941 | 15915 | 14885 |
| Only index persons | 27863 | 14799 | 13064 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.44 | 0.46 | 0.42 |
| Only index persons | 0.52 | 0.54 | 0.50 |
| Median age at first event (years) | |||
| Whole population | 68.04 | 69.82 | 66.22 |
| Only index persons | 68.95 | 70.43 | 67.26 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2720 | 1331 | 1389 |
| Unadjusted period prevalence (%) | 0.61 | 0.52 | 0.70 |
| Median age at first event (years) | 65.06 | 60.61 | 69.33 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H8_HL_NAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_HL_NAS | 1.051 [0.94, 1.18] | 0.386 |
| Birth year | 0.994 [0.99, 1.0] | 0.125 |
During the follow-up period (1.1.1998 — 31.12.2019), 3190 out of 11949 females with H8_HL_NAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_HL_NAS | 1.146 [1.0, 1.31] | 0.048 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 2866 out of 10220 males with H8_HL_NAS died.
Mortality risk
Mortality risk for people of age
years, who have H8_HL_NAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.097% | 0.217% |
| 5 | 0.537% | 1.333% |
| 10 | 1.297% | 3.267% |
| 15 | 2.614% | 6.252% |
| 20 | 4.635% | 10.136% |
Relationships between endpoints
↥Index endpoint: H8_HL_NAS – Other specified/unspecified hearing loss
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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