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Presbycusis

EFO MESH Endpoint Browser PheWeb

H8_HL_PRESBY

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H91.1
  • Hospital discharge: ICD-9 — 3880
  • Hospital discharge: excluded ICD-9 — 2880X
  • Cause of death: ICD-10 — H91.1
  • Cause of death: ICD-9 — 3880
  • Cause of death: excluded ICD-9 — 2880X

2 out of 7 registries used, show all original rules.

5286

4. Check minimum number of events

None

5286

5. Include endpoints

None

5286

6. Filter based on genotype QC (FinnGen only)

5091

Control definitions (FinnGen only)

Control exclude H8_OTHEREAR

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H91
Name in latin Presbyacusis

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 64425 38004 26033
Only index persons 55412 33250 22162
Unadjusted period prevalence (%)
Whole population 0.94 1.09 0.73
Only index persons 1.07 1.22 0.85
Median age at first event (years)
Whole population 80.01 81.05 78.51
Only index persons 79.56 80.63 77.95

-FinnGen-

Key figures

All Female Male
Number of individuals 5091 2320 2771
Unadjusted period prevalence (%) 1.17 0.91 1.39
Median age at first event (years) 76.68 76.69 76.67

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint H8_HL_PRESBY and mortality.

Females

Parameter HR [95% CI] p-value
H8_HL_PRESBY 0.901 [0.83, 0.98] 0.013
Birth year 0.994 [0.99, 1.0] 0.113

During the follow-up period (1.1.1998 — 31.12.2019), 17982 out of 34767 females with H8_HL_PRESBY died.

Males

Parameter HR [95% CI] p-value
H8_HL_PRESBY 0.939 [0.85, 1.03] 0.19
Birth year 0.987 [0.98, 1.0] 0.004

During the follow-up period (1.1.1998 — 31.12.2019), 12373 out of 23536 males with H8_HL_PRESBY died.

Mortality risk

Mortality risk for people of age

years, who have H8_HL_PRESBY.

N-year risk Females Males
1 0.082% 0.164%
5 0.533% 1.051%
10 1.268% 2.716%
15 2.457% 5.224%
20 4.262% 8.789%

Relationships between endpoints

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Index endpoint: H8_HL_PRESBY – Presbycusis

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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