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Deaf mutism, not elsewhere classified

EFO MESH Endpoint Browser PheWeb

H8_HL_DEAFMUT

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H91.3
  • Hospital discharge: ICD-9 — 3897
  • Hospital discharge: ICD-8 — 388
  • Cause of death: ICD-10 — H91.3
  • Cause of death: ICD-9 — 3897
  • Cause of death: ICD-8 — 388

2 out of 7 registries used, show all original rules.

180

4. Check minimum number of events

None

180

5. Include endpoints

None

180

6. Filter based on genotype QC (FinnGen only)

174

Control definitions (FinnGen only)

Control exclude H8_OTHEREAR

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H91
Name in latin Surdomutitas non alibi classificata

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2290 1093 1167
Only index persons 1776 903 873
Unadjusted period prevalence (%)
Whole population 0.03 0.03 0.03
Only index persons 0.03 0.03 0.03
Median age at first event (years)
Whole population 43.90 44.20 43.06
Only index persons 35.92 40.27 31.41

-FinnGen-

Key figures

All Female Male
Number of individuals 174 92 82
Unadjusted period prevalence (%) 0.04 0.04 0.04
Median age at first event (years) 48.02 44.34 52.15

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint H8_HL_DEAFMUT and mortality.

Females

Parameter HR [95% CI] p-value
H8_HL_DEAFMUT 0.972 [0.76, 1.25] 0.828
Birth year 0.994 [0.99, 1.0] 0.144

During the follow-up period (1.1.1998 — 31.12.2019), 84 out of 364 females with H8_HL_DEAFMUT died.

Males

Parameter HR [95% CI] p-value
H8_HL_DEAFMUT 1.274 [0.94, 1.72] 0.117
Birth year 0.988 [0.98, 1.0] 0.011

During the follow-up period (1.1.1998 — 31.12.2019), 94 out of 329 males with H8_HL_DEAFMUT died.

Mortality risk

Mortality risk for people of age

years, who have H8_HL_DEAFMUT.

N-year risk Females Males
1 0.062% 0.198%
5 0.475% 1.537%
10 1.164% 3.742%
15 2.581% 6.891%
20 4.467% 12.099%

Relationships between endpoints

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Index endpoint: H8_HL_DEAFMUT – Deaf mutism, not elsewhere classified

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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