Ototoxic hearing loss

H8_HL_OTOTOX

nonsyndromic deafness: An auditory system disease that is associated with permanent hearing loss caused by damage to structures in the inner ear and/or the middle ear, which is not associated with other signs and symptoms.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H91.0#
  • Cause of death: ICD-10 H91.0#

2 out of 7 registries used, show all original rules.

57

4. Check minimum number of events

None

57

5. Include endpoints

None

57

6. Filter based on genotype QC (FinnGen only)

56

Control definitions (FinnGen only)

Control exclude H8_OTHEREAR

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H91
Name in latin Hypacusis ototoxica

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 494 281 211
Only index persons 427 248 179
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 66.06 68.61 62.66
Only index persons 65.57 67.99 62.22

-FinnGen-

Key figures

All Female Male
Number of individuals 56 31 25
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 61.47 63.04 59.53

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint H8_HL_OTOTOX and mortality.

Females

Parameter HR [95% CI] p-value
H8_HL_OTOTOX 1.148 [0.87, 1.51] 0.324
Birth year 0.997 [0.99, 1.01] 0.517

During the follow-up period (1.1.1998 — 31.12.2019), 114 out of 265 females with H8_HL_OTOTOX died.

Males

Parameter HR [95% CI] p-value
H8_HL_OTOTOX 1.377 [0.94, 2.03] 0.104
Birth year 0.988 [0.98, 1.0] 0.013

During the follow-up period (1.1.1998 — 31.12.2019), 93 out of 204 males with H8_HL_OTOTOX died.

Mortality risk

Mortality risk for people of age

years, who have H8_HL_OTOTOX.

N-year risk Females Males
1 0.153% 0.281%
5 0.764% 1.75%
10 1.721% 4.524%
15 3.425% 8.169%
20 5.855% 13.591%

Relationships between endpoints

Index endpoint: H8_HL_OTOTOX – Ototoxic hearing loss

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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