nonsyndromic deafness: An auditory system disease that is associated with permanent hearing loss caused by damage to structures in the inner ear and/or the middle ear, which is not associated with other signs and symptoms.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
57 |
4. Check minimum number of eventsNone |
57 |
5. Include endpointsNone |
57 |
6. Filter based on genotype QC (FinnGen only) |
56 |
Control definitions (FinnGen only)
Control exclude
H8_OTHEREAR
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H91
Name in latin
Hypacusis ototoxica
Similar endpoints
↥List of similar endpoints to
Ototoxic hearing loss
based on the number of shared cases.
Similar with more cases:
- Other hearing loss
- Other disorders of ear
- Diseases of the ear and mastoid process
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 494 | 281 | 211 |
| Only index persons | 427 | 248 | 179 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 66.06 | 68.61 | 62.66 |
| Only index persons | 65.57 | 67.99 | 62.22 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 56 | 31 | 25 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | 61.47 | 63.04 | 59.53 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint H8_HL_OTOTOX and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_HL_OTOTOX | 1.148 [0.87, 1.51] | 0.324 |
| Birth year | 0.997 [0.99, 1.01] | 0.517 |
During the follow-up period (1.1.1998 — 31.12.2019), 114 out of 265 females with H8_HL_OTOTOX died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_HL_OTOTOX | 1.377 [0.94, 2.03] | 0.104 |
| Birth year | 0.988 [0.98, 1.0] | 0.013 |
During the follow-up period (1.1.1998 — 31.12.2019), 93 out of 204 males with H8_HL_OTOTOX died.
Mortality risk
Mortality risk for people of age
years, who have H8_HL_OTOTOX.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.153% | 0.281% |
| 5 | 0.764% | 1.75% |
| 10 | 1.721% | 4.524% |
| 15 | 3.425% | 8.169% |
| 20 | 5.855% | 13.591% |
Relationships between endpoints
↥Index endpoint: H8_HL_OTOTOX – Ototoxic hearing loss
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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