sensorineural hearing loss: Hearing loss in which the root cause lies in the inner ear or sensory organ (cochlea and associated structures) or the vestibulocochlear nerve (cranial nerve VIII).
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
3620 |
4. Check minimum number of eventsNone |
3620 |
5. Include endpointsNone |
3620 |
6. Filter based on genotype QC (FinnGen only) |
3487 |
Control definitions (FinnGen only)
Control exclude
H8_OTHEREAR
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H91
Name in latin
Hypacusis acuta idiopathica
Similar endpoints
↥List of similar endpoints to
Sudden idiopathic hearing loss
based on the number of shared cases.
Similar with more cases:
- Other hearing loss
- Other disorders of ear
- Diseases of the ear and mastoid process
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 24447 | 12128 | 12214 |
| Only index persons | 23111 | 11603 | 11508 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.34 | 0.35 | 0.34 |
| Only index persons | 0.43 | 0.43 | 0.44 |
| Median age at first event (years) | |||
| Whole population | 58.15 | 58.52 | 57.78 |
| Only index persons | 57.56 | 57.96 | 57.15 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 3487 | 1806 | 1681 |
| Unadjusted period prevalence (%) | 0.77 | 0.71 | 0.84 |
| Median age at first event (years) | 58.24 | 56.13 | 60.50 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H8_HL_IDIOP and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_HL_IDIOP | 0.9 [0.82, 0.99] | 0.036 |
| Birth year | 0.997 [0.99, 1.01] | 0.47 |
During the follow-up period (1.1.1998 — 31.12.2019), 1342 out of 9703 females with H8_HL_IDIOP died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_HL_IDIOP | 0.86 [0.78, 0.95] | 0.003 |
| Birth year | 0.988 [0.98, 1.0] | 0.016 |
During the follow-up period (1.1.1998 — 31.12.2019), 1633 out of 9777 males with H8_HL_IDIOP died.
Mortality risk
Mortality risk for people of age
years, who have H8_HL_IDIOP.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.085% | 0.141% |
| 5 | 0.603% | 0.918% |
| 10 | 1.326% | 2.653% |
| 15 | 2.72% | 4.967% |
| 20 | 4.618% | 8.504% |
Relationships between endpoints
↥Index endpoint: H8_HL_IDIOP – Sudden idiopathic hearing loss
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data