sensorineural hearing loss: Hearing loss in which the root cause lies in the inner ear or sensory organ (cochlea and associated structures) or the vestibulocochlear nerve (cranial nerve VIII).
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
41047 |
4. Check minimum number of eventsNone |
41047 |
5. Include endpointsNone |
41047 |
6. Filter based on genotype QC (FinnGen only) |
39620 |
Control definitions (FinnGen only)
Control exclude
H8_OTHEREAR
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Sensorineural hearing loss
based on the number of shared cases.
Similar with more cases:
- Conductive and sensorineural hearing loss
- Other disorders of ear
- Diseases of the ear and mastoid process
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 338155 | 170591 | 166044 |
| Only index persons | 312784 | 160345 | 152439 |
| Unadjusted period prevalence (%) | |||
| Whole population | 4.75 | 4.89 | 4.64 |
| Only index persons | 5.86 | 5.89 | 5.82 |
| Median age at first event (years) | |||
| Whole population | 69.30 | 70.58 | 67.94 |
| Only index persons | 68.52 | 69.85 | 67.12 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 39620 | 18743 | 20877 |
| Unadjusted period prevalence (%) | 9.01 | 7.36 | 10.48 |
| Median age at first event (years) | 66.47 | 64.29 | 68.42 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H8_HL_SEN_NAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_HL_SEN_NAS | 0.875 [0.81, 0.95] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.118 |
During the follow-up period (1.1.1998 — 31.12.2019), 42871 out of 154079 females with H8_HL_SEN_NAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_HL_SEN_NAS | 0.814 [0.75, 0.88] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.01 |
During the follow-up period (1.1.1998 — 31.12.2019), 43889 out of 148777 males with H8_HL_SEN_NAS died.
Mortality risk
Mortality risk for people of age
years, who have H8_HL_SEN_NAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.065% | 0.132% |
| 5 | 0.457% | 0.951% |
| 10 | 1.228% | 2.317% |
| 15 | 2.285% | 4.503% |
| 20 | 4.091% | 7.64% |
Relationships between endpoints
↥Index endpoint: H8_HL_SEN_NAS – Sensorineural hearing loss
GWS hits: 31
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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