Otalgia

H8_OTALGIA

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H92.0
  • Cause of death: ICD-10 H92.0

2 out of 7 registries used, show all original rules.

2758

4. Check minimum number of events

None

2758

5. Include endpoints

None

2758

6. Filter based on genotype QC (FinnGen only)

2646

Control definitions (FinnGen only)

Control exclude H8_OTHEREAR

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H92
Name in latin Otalgia

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 32065 19376 12536
Only index persons 23581 15251 8330
Unadjusted period prevalence (%)
Whole population 0.47 0.55 0.35
Only index persons 0.47 0.56 0.32
Median age at first event (years)
Whole population 20.62 26.65 11.14
Only index persons 34.95 38.44 28.57

-FinnGen-

Key figures

All Female Male
Number of individuals 2646 1965 681
Unadjusted period prevalence (%) 0.66 0.77 0.34
Median age at first event (years) 52.72 51.33 56.74

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint H8_OTALGIA and mortality.

Females

Parameter HR [95% CI] p-value
H8_OTALGIA 0.943 [0.81, 1.1] 0.442
Birth year 0.995 [0.99, 1.0] 0.29

During the follow-up period (1.1.1998 — 31.12.2019), 730 out of 15561 females with H8_OTALGIA died.

Males

Parameter HR [95% CI] p-value
H8_OTALGIA 0.972 [0.82, 1.16] 0.753
Birth year 0.987 [0.98, 1.0] 0.008

During the follow-up period (1.1.1998 — 31.12.2019), 478 out of 9967 males with H8_OTALGIA died.

Mortality risk

Mortality risk for people of age

years, who have H8_OTALGIA.

N-year risk Females Males
1 0.104% 0.154%
5 0.657% 1.016%
10 1.497% 2.768%
15 2.837% 5.451%
20 4.958% 9.074%

Relationships between endpoints

Index endpoint: H8_OTALGIA – Otalgia

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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