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Other bacterial diseases

DOID EFO Endpoint Browser PheWeb

AB1_OTHER_BACTERIAL

erysipelas: an infection of the upper layers of the skin caused by species of streptococcus. Erysipelas results in a fiery red rash with raised edges that can easily be distinguished from the skin around it. The affected skin may be warm to the touch.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — A30-A49
  • Hospital discharge: ICD-9 — 03[0-9]|04[0-1]|0880
  • Hospital discharge: ICD-8 — 03[0-9]
  • Hospital discharge: excluded ICD-9 — 034[0-0]
  • Hospital discharge: excluded ICD-8 — 034[0-0]
  • Cause of death: ICD-10 — A30-A49
  • Cause of death: ICD-9 — 03[0-9]|04[0-1]|0880
  • Cause of death: ICD-8 — 03[0-9]
  • Cause of death: excluded ICD-9 — 034[0-0]
  • Cause of death: excluded ICD-8 — 034[0-0]

2 out of 7 registries used, show all original rules.

56641

4. Check minimum number of events

None

56641

5. Include endpoints

56663

6. Filter based on genotype QC (FinnGen only)

54584

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF5

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 560275 265832 289990
Only index persons 464286 221310 242976
Unadjusted period prevalence (%)
Whole population 7.84 7.61 8.10
Only index persons 8.73 8.14 9.28
Median age at first event (years)
Whole population 65.47 68.61 62.57
Only index persons 64.58 67.63 61.81

-FinnGen-

Key figures

All Female Male
Number of individuals 54584 24493 30091
Unadjusted period prevalence (%) 12.65 9.62 15.11
Median age at first event (years) 63.67 61.46 65.46

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint AB1_OTHER_BACTERIAL and mortality.

Females

Parameter HR [95% CI] p-value
AB1_OTHER_BACTERIAL 2.605 [2.38, 2.85] < 0.001
Birth year 0.988 [0.98, 1.0] 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 73702 out of 187003 females with AB1_OTHER_BACTERIAL died.

Males

Parameter HR [95% CI] p-value
AB1_OTHER_BACTERIAL 3.064 [2.77, 3.38] < 0.001
Birth year 0.978 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 77127 out of 204263 males with AB1_OTHER_BACTERIAL died.

Mortality risk

Mortality risk for people of age

years, who have AB1_OTHER_BACTERIAL.

N-year risk Females Males
1 0.172% 0.375%
5 1.028% 1.946%
10 2.381% 4.754%
15 4.644% 8.846%
20 7.694% 14.572%

Relationships between endpoints

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Index endpoint: AB1_OTHER_BACTERIAL – Other bacterial diseases

GWS hits: 3

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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