Erysipelas

AB1_ERYSIPELAS

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 A46
  • Hospital discharge: ICD-9 03[5]
  • Hospital discharge: ICD-8 03[5]
  • Cause of death: ICD-10 A46
  • Cause of death: ICD-9 03[5]
  • Cause of death: ICD-8 03[5]

2 out of 7 registries used, show all original rules.

25685

4. Check minimum number of events

None

25685

5. Include endpoints

None

25685

6. Filter based on genotype QC (FinnGen only)

24825

Control definitions (FinnGen only)

Control exclude AB1_OTHER_BACTERIAL

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF5

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 251995 115077 135073
Only index persons 211368 95437 115931
Unadjusted period prevalence (%)
Whole population 3.54 3.30 3.77
Only index persons 4.01 3.51 4.43
Median age at first event (years)
Whole population 63.26 68.33 58.90
Only index persons 61.77 66.77 57.66

-FinnGen-

Key figures

All Female Male
Number of individuals 24825 10511 14314
Unadjusted period prevalence (%) 5.89 4.13 7.19
Median age at first event (years) 60.93 60.77 61.05

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint AB1_ERYSIPELAS and mortality.

Females

Parameter HR [95% CI] p-value
AB1_ERYSIPELAS 1.858 [1.7, 2.03] < 0.001
Birth year 0.993 [0.98, 1.0] 0.126

During the follow-up period (1.1.1998 — 31.12.2019), 32407 out of 82425 females with AB1_ERYSIPELAS died.

Males

Parameter HR [95% CI] p-value
AB1_ERYSIPELAS 2.1 [1.9, 2.32] < 0.001
Birth year 0.984 [0.98, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 32243 out of 99656 males with AB1_ERYSIPELAS died.

Mortality risk

Mortality risk for people of age

years, who have AB1_ERYSIPELAS.

N-year risk Females Males
1 0.132% 0.314%
5 0.845% 1.973%
10 2.212% 5.106%
15 4.201% 9.628%
20 7.784% 15.482%

Relationships between endpoints

Index endpoint: AB1_ERYSIPELAS – Erysipelas

GWS hits: 4

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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