≡ Risteys
FG R11 + FR

Documentation Changelog GitHub Contact & Feedback

Other septicaemia

EFO Endpoint Browser PheWeb

AB1_OTHER_SEPSIS

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — A41
  • Hospital discharge: ICD-9 — 03[8]
  • Hospital discharge: ICD-8 — 03[8]
  • Hospital discharge: excluded ICD-9 — 038[0]
  • Hospital discharge: excluded ICD-8 — 038[0]
  • Cause of death: ICD-10 — A41
  • Cause of death: ICD-9 — 03[8]
  • Cause of death: ICD-8 — 03[8]
  • Cause of death: excluded ICD-9 — 038[0]
  • Cause of death: excluded ICD-8 — 038[0]

2 out of 7 registries used, show all original rules.

15742

4. Check minimum number of events

None

15742

5. Include endpoints

None

15742

6. Filter based on genotype QC (FinnGen only)

15156

Control definitions (FinnGen only)

Control exclude AB1_OTHER_BACTERIAL

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF5

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 167569 82004 83799
Only index persons 128534 63898 64636
Unadjusted period prevalence (%)
Whole population 2.34 2.35 2.34
Only index persons 2.41 2.35 2.47
Median age at first event (years)
Whole population 69.43 71.42 67.48
Only index persons 69.17 70.97 67.40

-FinnGen-

Key figures

All Female Male
Number of individuals 15156 6803 8353
Unadjusted period prevalence (%) 3.51 2.67 4.20
Median age at first event (years) 67.42 64.74 69.61

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

↥

Association

Association between endpoint AB1_OTHER_SEPSIS and mortality.

Females

Parameter HR [95% CI] p-value
AB1_OTHER_SEPSIS 3.124 [2.78, 3.51] < 0.001
Birth year 0.995 [0.99, 1.0] 0.175

During the follow-up period (1.1.1998 — 31.12.2019), 23117 out of 51517 females with AB1_OTHER_SEPSIS died.

Males

Parameter HR [95% CI] p-value
AB1_OTHER_SEPSIS 3.712 [3.24, 4.26] < 0.001
Birth year 0.986 [0.98, 0.99] 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 23592 out of 50995 males with AB1_OTHER_SEPSIS died.

Mortality risk

Mortality risk for people of age

years, who have AB1_OTHER_SEPSIS.

N-year risk Females Males
1 0.203% 0.495%
5 1.633% 3.551%
10 4.221% 8.422%
15 8.361% 16.01%
20 13.582% 26.003%

Relationships between endpoints

↥

Index endpoint: AB1_OTHER_SEPSIS – Other septicaemia

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data