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Meningococcal infection

EFO Endpoint Browser PheWeb

AB1_MENINGOCOCCAL

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — A39
  • Hospital discharge: ICD-9 — 03[6]
  • Hospital discharge: ICD-8 — 03[6]
  • Cause of death: ICD-10 — A39
  • Cause of death: ICD-9 — 03[6]
  • Cause of death: ICD-8 — 03[6]

2 out of 7 registries used, show all original rules.

267

4. Check minimum number of events

None

267

5. Include endpoints

None

267

6. Filter based on genotype QC (FinnGen only)

253

Control definitions (FinnGen only)

Control exclude AB1_OTHER_BACTERIAL

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF5

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3391 1544 1828
Only index persons 2683 1246 1437
Unadjusted period prevalence (%)
Whole population 0.05 0.04 0.05
Only index persons 0.05 0.05 0.05
Median age at first event (years)
Whole population 17.73 17.89 17.27
Only index persons 16.06 16.30 15.85

-FinnGen-

Key figures

All Female Male
Number of individuals 253 140 113
Unadjusted period prevalence (%) 0.06 0.05 0.06
Median age at first event (years) 17.93 17.30 18.71

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint AB1_MENINGOCOCCAL and mortality.

Females

Parameter HR [95% CI] p-value
AB1_MENINGOCOCCAL 2.491 [1.73, 3.59] < 0.001
Birth year 0.997 [0.99, 1.01] 0.475

During the follow-up period (1.1.1998 — 31.12.2019), 101 out of 463 females with AB1_MENINGOCOCCAL died.

Males

Parameter HR [95% CI] p-value
AB1_MENINGOCOCCAL 2.574 [1.72, 3.86] < 0.001
Birth year 0.989 [0.98, 1.0] 0.054

During the follow-up period (1.1.1998 — 31.12.2019), 82 out of 513 males with AB1_MENINGOCOCCAL died.

Mortality risk

Mortality risk for people of age

years, who have AB1_MENINGOCOCCAL.

N-year risk Females Males
1 0.184% 0.429%
5 1.429% 2.889%
10 3.829% 7.419%
15 7.655% 14.077%
20 13.33% 23.471%

Relationships between endpoints

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Index endpoint: AB1_MENINGOCOCCAL – Meningococcal infection

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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