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This is a non-core endpoint: only basic statistics are computed.

Nocardiosis

AB1_NOCARDIOSIS

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 A43
  • Cause of death: ICD-10 A43

2 out of 7 registries used, show all original rules.

32

4. Check minimum number of events

None

32

5. Include endpoints

None

32

6. Filter based on genotype QC (FinnGen only)

28

Control definitions (FinnGen only)

Control exclude AB1_OTHER_BACTERIAL

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF5

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 241 107 132
Only index persons 196 83 113
Unadjusted period prevalence (%)
Whole population 0.00 0.00 0.00
Only index persons 0.00 0.00 0.00
Median age at first event (years)
Whole population 62.77 64.15 61.68
Only index persons 60.79 59.96 61.40

-FinnGen-

Key figures

All Female Male
Number of individuals 28 10 18
Unadjusted period prevalence (%) 0.01 0.00 0.01
Median age at first event (years) 65.73 66.17 65.48

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

Mortality – FinRegistry

Association

Association between endpoint AB1_NOCARDIOSIS and mortality.

Females

No data

Males

Parameter HR [95% CI] p-value
AB1_NOCARDIOSIS 3.248 [1.86, 5.68] < 0.001
Birth year 0.983 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 52 out of 117 males with AB1_NOCARDIOSIS died.

Mortality risk

Mortality risk for people of age

years, who have AB1_NOCARDIOSIS.

N-year risk Females Males
1 No data 0.523%
5 No data 3.446%
10 No data 8.776%
15 No data 15.743%
20 No data 25.32%

Relationships between endpoints

Index endpoint: AB1_NOCARDIOSIS – Nocardiosis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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