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Infection due to other mycobacteria

EFO Endpoint Browser PheWeb

AB1_OTHER_MYCOBAC

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — A31
  • Hospital discharge: ICD-9 — 03[1]
  • Hospital discharge: ICD-8 — 03[1]
  • Cause of death: ICD-10 — A31
  • Cause of death: ICD-9 — 03[1]
  • Cause of death: ICD-8 — 03[1]

2 out of 7 registries used, show all original rules.

490

4. Check minimum number of events

None

490

5. Include endpoints

None

490

6. Filter based on genotype QC (FinnGen only)

467

Control definitions (FinnGen only)

Control exclude AB1_OTHER_BACTERIAL

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF5

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 4384 2364 1935
Only index persons 2970 1735 1235
Unadjusted period prevalence (%)
Whole population 0.06 0.07 0.05
Only index persons 0.06 0.06 0.05
Median age at first event (years)
Whole population 67.61 68.82 66.10
Only index persons 66.78 68.03 65.03

-FinnGen-

Key figures

All Female Male
Number of individuals 467 249 218
Unadjusted period prevalence (%) 0.10 0.10 0.11
Median age at first event (years) 65.23 63.15 67.61

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint AB1_OTHER_MYCOBAC and mortality.

Females

Parameter HR [95% CI] p-value
AB1_OTHER_MYCOBAC 1.906 [1.65, 2.2] < 0.001
Birth year 0.993 [0.98, 1.0] 0.125

During the follow-up period (1.1.1998 — 31.12.2019), 658 out of 1676 females with AB1_OTHER_MYCOBAC died.

Males

Parameter HR [95% CI] p-value
AB1_OTHER_MYCOBAC 2.693 [2.15, 3.37] < 0.001
Birth year 0.983 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 619 out of 1250 males with AB1_OTHER_MYCOBAC died.

Mortality risk

Mortality risk for people of age

years, who have AB1_OTHER_MYCOBAC.

N-year risk Females Males
1 0.197% 0.472%
5 1.066% 2.948%
10 2.455% 6.89%
15 4.73% 12.749%
20 8.37% 21.26%

Relationships between endpoints

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Index endpoint: AB1_OTHER_MYCOBAC – Infection due to other mycobacteria

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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