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Actinomycosis

EFO Endpoint Browser PheWeb

AB1_ACTINOMYCOSIS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — A42
  • Hospital discharge: ICD-9 — 03[9]
  • Hospital discharge: ICD-8 — 113
  • Cause of death: ICD-10 — A42
  • Cause of death: ICD-9 — 03[9]
  • Cause of death: ICD-8 — 113

2 out of 7 registries used, show all original rules.

123

4. Check minimum number of events

None

123

5. Include endpoints

None

123

6. Filter based on genotype QC (FinnGen only)

113

Control definitions (FinnGen only)

Control exclude AB1_OTHER_BACTERIAL

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF5

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1062 550 497
Only index persons 861 471 390
Unadjusted period prevalence (%)
Whole population 0.01 0.02 0.01
Only index persons 0.02 0.02 0.01
Median age at first event (years)
Whole population 55.29 54.14 56.58
Only index persons 53.82 51.92 56.12

-FinnGen-

Key figures

All Female Male
Number of individuals 113 56 57
Unadjusted period prevalence (%) 0.03 0.02 0.03
Median age at first event (years) 56.17 51.96 60.31

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint AB1_ACTINOMYCOSIS and mortality.

Females

Parameter HR [95% CI] p-value
AB1_ACTINOMYCOSIS 2.689 [1.86, 3.89] < 0.001
Birth year 0.993 [0.98, 1.0] 0.106

During the follow-up period (1.1.1998 — 31.12.2019), 115 out of 379 females with AB1_ACTINOMYCOSIS died.

Males

Parameter HR [95% CI] p-value
AB1_ACTINOMYCOSIS 2.634 [1.72, 4.04] < 0.001
Birth year 0.986 [0.92, 1.06] 0.71

During the follow-up period (1.1.1998 — 31.12.2019), 117 out of 311 males with AB1_ACTINOMYCOSIS died.

Mortality risk

Mortality risk for people of age

years, who have AB1_ACTINOMYCOSIS.

N-year risk Females Males
1 0.302% 0.443%
5 1.582% 2.883%
10 3.754% 6.931%
15 7.205% 12.935%
20 12.092% 21.402%

Relationships between endpoints

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Index endpoint: AB1_ACTINOMYCOSIS – Actinomycosis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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