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Listeriosis

EFO Endpoint Browser PheWeb

AB1_LISTERIOSIS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — A32
  • Hospital discharge: ICD-9 — 027[0]
  • Hospital discharge: ICD-8 — 027[0]
  • Cause of death: ICD-10 — A32
  • Cause of death: ICD-9 — 027[0]
  • Cause of death: ICD-8 — 027[0]

2 out of 7 registries used, show all original rules.

145

4. Check minimum number of events

None

145

5. Include endpoints

None

145

6. Filter based on genotype QC (FinnGen only)

137

Control definitions (FinnGen only)

Control exclude AB1_OTHER_BACTERIAL

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF5

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1333 676 639
Only index persons 984 554 430
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.02
Only index persons 0.02 0.02 0.02
Median age at first event (years)
Whole population 69.92 69.30 70.68
Only index persons 70.94 69.41 72.91

-FinnGen-

Key figures

All Female Male
Number of individuals 137 69 68
Unadjusted period prevalence (%) 0.03 0.03 0.03
Median age at first event (years) 68.64 64.80 72.55

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint AB1_LISTERIOSIS and mortality.

Females

Parameter HR [95% CI] p-value
AB1_LISTERIOSIS 4.859 [2.89, 8.17] < 0.001
Birth year 0.999 [0.99, 1.01] 0.824

During the follow-up period (1.1.1998 — 31.12.2019), 205 out of 348 females with AB1_LISTERIOSIS died.

Males

Parameter HR [95% CI] p-value
AB1_LISTERIOSIS 4.353 [2.43, 7.78] < 0.001
Birth year 0.985 [0.98, 1.0] 0.006

During the follow-up period (1.1.1998 — 31.12.2019), 223 out of 356 males with AB1_LISTERIOSIS died.

Mortality risk

Mortality risk for people of age

years, who have AB1_LISTERIOSIS.

N-year risk Females Males
1 0.565% 0.673%
5 3.177% 4.698%
10 7.736% 11.197%
15 14.768% 20.144%
20 25.68% 32.273%

Relationships between endpoints

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Index endpoint: AB1_LISTERIOSIS – Listeriosis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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