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Streptococcal septicaemia

EFO Endpoint Browser PheWeb

AB1_STREPTO_SEPSIS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — A40
  • Hospital discharge: ICD-9 — 038[0]
  • Hospital discharge: ICD-8 — 038[0]
  • Cause of death: ICD-10 — A40
  • Cause of death: ICD-9 — 038[0]
  • Cause of death: ICD-8 — 038[0]

2 out of 7 registries used, show all original rules.

2978

4. Check minimum number of events

None

2978

5. Include endpoints

None

2978

6. Filter based on genotype QC (FinnGen only)

2846

Control definitions (FinnGen only)

Control exclude AB1_OTHER_BACTERIAL

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF5

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 30449 13253 16974
Only index persons 24844 10973 13871
Unadjusted period prevalence (%)
Whole population 0.43 0.38 0.47
Only index persons 0.47 0.40 0.53
Median age at first event (years)
Whole population 60.80 62.34 59.49
Only index persons 60.39 61.75 59.32

-FinnGen-

Key figures

All Female Male
Number of individuals 2846 1132 1714
Unadjusted period prevalence (%) 0.70 0.44 0.86
Median age at first event (years) 64.34 59.94 67.25

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint AB1_STREPTO_SEPSIS and mortality.

Females

Parameter HR [95% CI] p-value
AB1_STREPTO_SEPSIS 2.884 [2.5, 3.33] < 0.001
Birth year 0.995 [0.99, 1.0] 0.19

During the follow-up period (1.1.1998 — 31.12.2019), 2934 out of 9755 females with AB1_STREPTO_SEPSIS died.

Males

Parameter HR [95% CI] p-value
AB1_STREPTO_SEPSIS 3.242 [2.81, 3.74] < 0.001
Birth year 0.986 [0.98, 1.0] 0.004

During the follow-up period (1.1.1998 — 31.12.2019), 4143 out of 12444 males with AB1_STREPTO_SEPSIS died.

Mortality risk

Mortality risk for people of age

years, who have AB1_STREPTO_SEPSIS.

N-year risk Females Males
1 0.266% 0.621%
5 1.546% 3.367%
10 3.906% 8.524%
15 7.522% 15.631%
20 13.365% 25.987%

Relationships between endpoints

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Index endpoint: AB1_STREPTO_SEPSIS – Streptococcal septicaemia

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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