intestinal volvulus: A twisting in the intestine (INTESTINES) that can cause INTESTINAL OBSTRUCTION.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
84076 |
4. Check minimum number of eventsNone |
84076 |
5. Include endpoints |
96767 |
6. Filter based on genotype QC (FinnGen only) |
93340 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Other diseases of intestines
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 870913 | 477899 | 385510 |
| Only index persons | 714835 | 403729 | 311106 |
| Unadjusted period prevalence (%) | |||
| Whole population | 12.35 | 13.69 | 10.77 |
| Only index persons | 13.55 | 14.84 | 11.88 |
| Median age at first event (years) | |||
| Whole population | 57.28 | 58.78 | 55.32 |
| Only index persons | 55.41 | 56.92 | 53.45 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 93340 | 52568 | 40772 |
| Unadjusted period prevalence (%) | 20.57 | 20.65 | 20.48 |
| Median age at first event (years) | 56.91 | 54.90 | 59.50 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint K11_INTESTOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_INTESTOTH | 1.554 [1.44, 1.68] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.01 |
During the follow-up period (1.1.1998 — 31.12.2019), 71774 out of 305558 females with K11_INTESTOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_INTESTOTH | 1.712 [1.57, 1.87] | < 0.001 |
| Birth year | 0.982 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 62032 out of 234215 males with K11_INTESTOTH died.
Mortality risk
Mortality risk for people of age
years, who have K11_INTESTOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.151% | 0.233% |
| 5 | 0.688% | 1.485% |
| 10 | 1.548% | 3.587% |
| 15 | 2.993% | 6.711% |
| 20 | 5.282% | 11.322% |
Relationships between endpoints
↥Index endpoint: K11_INTESTOTH – Other diseases of intestines
GWS hits: 11
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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