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Other diseases of intestine

DOID EFO Endpoint Browser PheWeb

K11_OTHINT

intestinal disease: A non-neoplastic or neoplastic disorder that affects the small or large intestine.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — K63
  • Hospital discharge: ICD-9 — 569[5-9]
  • Hospital discharge: ICD-8 — 569
  • Hospital discharge: excluded ICD-8 — 5690[6-7]
  • Cause of death: ICD-10 — K63
  • Cause of death: ICD-9 — 569[5-9]
  • Cause of death: ICD-8 — 569
  • Cause of death: excluded ICD-8 — 5690[6-7]

2 out of 7 registries used, show all original rules.

4237

4. Check minimum number of events

None

4237

5. Include endpoints

None

4237

6. Filter based on genotype QC (FinnGen only)

4081

Control definitions (FinnGen only)

Control exclude K11_INTESTOTH

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 K55-K63
Name in latin Alii morbi intestini

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 35557 18270 16907
Only index persons 28068 14716 13352
Unadjusted period prevalence (%)
Whole population 0.50 0.52 0.47
Only index persons 0.53 0.54 0.51
Median age at first event (years)
Whole population 64.22 65.59 62.79
Only index persons 63.47 64.36 62.49

-FinnGen-

Key figures

All Female Male
Number of individuals 4081 1995 2086
Unadjusted period prevalence (%) 0.92 0.78 1.05
Median age at first event (years) 63.91 61.61 66.11

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint K11_OTHINT and mortality.

Females

Parameter HR [95% CI] p-value
K11_OTHINT 2.269 [2.0, 2.57] < 0.001
Birth year 0.996 [0.99, 1.0] 0.275

During the follow-up period (1.1.1998 — 31.12.2019), 2745 out of 8346 females with K11_OTHINT died.

Males

Parameter HR [95% CI] p-value
K11_OTHINT 2.521 [2.18, 2.92] < 0.001
Birth year 0.987 [0.98, 1.0] 0.008

During the follow-up period (1.1.1998 — 31.12.2019), 2777 out of 8156 males with K11_OTHINT died.

Mortality risk

Mortality risk for people of age

years, who have K11_OTHINT.

N-year risk Females Males
1 0.175% 0.453%
5 1.332% 2.727%
10 3.489% 6.975%
15 6.572% 13.4%
20 11.598% 22.801%

Relationships between endpoints

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Index endpoint: K11_OTHINT – Other diseases of intestine

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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