No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
39132 |
4. Check minimum number of eventsNone |
39132 |
5. Include endpointsNone |
39132 |
6. Filter based on genotype QC (FinnGen only) |
37886 |
Control definitions (FinnGen only)
Control exclude
K11_INTESTOTH
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
K55-K63
Name in latin
Diverticulosis intestini
Diverticular disease of intestine
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 299258 | 178439 | 118920 |
| Only index persons | 261351 | 157729 | 103622 |
| Unadjusted period prevalence (%) | |||
| Whole population | 4.38 | 5.11 | 3.32 |
| Only index persons | 5.07 | 5.80 | 3.96 |
| Median age at first event (years) | |||
| Whole population | 67.39 | 68.44 | 65.76 |
| Only index persons | 66.29 | 67.33 | 64.69 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 37886 | 21764 | 16122 |
| Unadjusted period prevalence (%) | 8.36 | 8.55 | 8.10 |
| Median age at first event (years) | 65.02 | 64.10 | 66.27 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint K11_DIVERTIC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_DIVERTIC | 1.166 [1.08, 1.26] | < 0.001 |
| Birth year | 0.993 [0.99, 1.0] | 0.089 |
During the follow-up period (1.1.1998 — 31.12.2019), 35139 out of 136211 females with K11_DIVERTIC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_DIVERTIC | 1.278 [1.17, 1.4] | < 0.001 |
| Birth year | 0.984 [0.98, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 25793 out of 90442 males with K11_DIVERTIC died.
Mortality risk
Mortality risk for people of age
years, who have K11_DIVERTIC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.098% | 0.174% |
| 5 | 0.626% | 1.202% |
| 10 | 1.517% | 3.079% |
| 15 | 2.873% | 5.976% |
| 20 | 5.012% | 9.993% |
Relationships between endpoints
↥Index endpoint: K11_DIVERTIC – Diverticular disease of intestine
GWS hits: 67
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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