irritable bowel syndrome: Gastrointestinal symptoms characterized by chronic abdominal pain and altered bowel habits in the absence of any organic cause.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
12189 |
4. Check minimum number of eventsNone |
12189 |
5. Include endpointsNone |
12189 |
6. Filter based on genotype QC (FinnGen only) |
11742 |
Control definitions (FinnGen only)
Control exclude
K11_INTESTOTH
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
K55-K63
Name in latin
Syndroma intestini irritabilis
Irritable bowel syndrome
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 86289 | 59691 | 26108 |
| Only index persons | 80007 | 56165 | 23842 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.41 | 1.71 | 0.73 |
| Only index persons | 1.72 | 2.06 | 0.91 |
| Median age at first event (years) | |||
| Whole population | 48.52 | 49.46 | 46.36 |
| Only index persons | 47.41 | 48.38 | 45.12 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 11742 | 8704 | 3038 |
| Unadjusted period prevalence (%) | 2.93 | 3.42 | 1.53 |
| Median age at first event (years) | 49.43 | 48.42 | 52.31 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint K11_IBS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_IBS | 0.973 [0.89, 1.06] | 0.544 |
| Birth year | 0.994 [0.99, 1.0] | 0.184 |
During the follow-up period (1.1.1998 — 31.12.2019), 4239 out of 45753 females with K11_IBS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_IBS | 1.061 [0.96, 1.17] | 0.237 |
| Birth year | 0.988 [0.98, 1.0] | 0.009 |
During the follow-up period (1.1.1998 — 31.12.2019), 2426 out of 18955 males with K11_IBS died.
Mortality risk
Mortality risk for people of age
years, who have K11_IBS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.084% | 0.21% |
| 5 | 0.593% | 1.221% |
| 10 | 1.48% | 3.047% |
| 15 | 2.862% | 5.734% |
| 20 | 4.893% | 9.89% |
Relationships between endpoints
↥Index endpoint: K11_IBS – Irritable bowel syndrome
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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