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Abscess of anal and rectal regions

DOID EFO Endpoint Browser PheWeb

K11_ABSCANAL

rectal disease: A disease that involves the rectum. [database_cross_reference: MONDO:patterns/location]

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — K61
  • Hospital discharge: ICD-9 — 566
  • Hospital discharge: ICD-8 — 566
  • Cause of death: ICD-10 — K61
  • Cause of death: ICD-9 — 566
  • Cause of death: ICD-8 — 566

2 out of 7 registries used, show all original rules.

3329

4. Check minimum number of events

None

3329

5. Include endpoints

None

3329

6. Filter based on genotype QC (FinnGen only)

3210

Control definitions (FinnGen only)

Control exclude K11_INTESTOTH

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 K55-K63
Name in latin Abscessus seu cellulitis regionis analis/rectalis

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 30472 8948 21312
Only index persons 26981 8210 18771
Unadjusted period prevalence (%)
Whole population 0.49 0.26 0.60
Only index persons 0.59 0.30 0.72
Median age at first event (years)
Whole population 40.85 42.39 40.14
Only index persons 40.16 41.46 39.59

-FinnGen-

Key figures

All Female Male
Number of individuals 3210 1225 1985
Unadjusted period prevalence (%) 0.80 0.48 1.00
Median age at first event (years) 44.04 41.52 45.60

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint K11_ABSCANAL and mortality.

Females

Parameter HR [95% CI] p-value
K11_ABSCANAL 2.182 [1.89, 2.52] < 0.001
Birth year 1.002 [0.99, 1.01] 0.616

During the follow-up period (1.1.1998 — 31.12.2019), 696 out of 6027 females with K11_ABSCANAL died.

Males

Parameter HR [95% CI] p-value
K11_ABSCANAL 2.027 [1.82, 2.26] < 0.001
Birth year 0.991 [0.98, 1.0] 0.038

During the follow-up period (1.1.1998 — 31.12.2019), 1799 out of 14401 males with K11_ABSCANAL died.

Mortality risk

Mortality risk for people of age

years, who have K11_ABSCANAL.

N-year risk Females Males
1 0.3% 0.403%
5 1.548% 2.447%
10 3.758% 5.958%
15 7.344% 11.286%
20 12.987% 19.161%

Relationships between endpoints

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Index endpoint: K11_ABSCANAL – Abscess of anal and rectal regions

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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