intestinal pseudo-obstruction: A type of ILEUS, a functional not mechanical obstruction of the INTESTINES. This syndrome is caused by a large number of disorders involving the smooth muscles (MUSCLE, SMOOTH) or the NERVOUS SYSTEM.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
9564 |
4. Check minimum number of eventsNone |
9564 |
5. Include endpoints |
10780 |
6. Filter based on genotype QC (FinnGen only) |
10403 |
Control definitions (FinnGen only)
Control exclude
K11_INTESTOTH
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
K55-K63
Name in latin
Ileus paralyticus sive obstructio intestini sine hernia
Paralytic ileus and intestinal obstruction
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 110373 | 57288 | 51704 |
| Only index persons | 81601 | 43380 | 38221 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.55 | 1.64 | 1.44 |
| Only index persons | 1.53 | 1.59 | 1.46 |
| Median age at first event (years) | |||
| Whole population | 67.25 | 68.25 | 66.07 |
| Only index persons | 65.10 | 65.75 | 64.37 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 10403 | 5124 | 5279 |
| Unadjusted period prevalence (%) | 2.34 | 2.01 | 2.65 |
| Median age at first event (years) | 62.72 | 59.16 | 66.19 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint K11_ILEUS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_ILEUS | 2.51 [2.28, 2.77] | < 0.001 |
| Birth year | 0.993 [0.99, 1.0] | 0.101 |
During the follow-up period (1.1.1998 — 31.12.2019), 15397 out of 34140 females with K11_ILEUS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_ILEUS | 2.46 [2.2, 2.75] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 14525 out of 31020 males with K11_ILEUS died.
Mortality risk
Mortality risk for people of age
years, who have K11_ILEUS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.267% | 0.525% |
| 5 | 1.3% | 2.784% |
| 10 | 3.286% | 6.393% |
| 15 | 6.189% | 11.797% |
| 20 | 10.969% | 19.532% |
Relationships between endpoints
↥Index endpoint: K11_ILEUS – Paralytic ileus and intestinal obstruction
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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