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Paralytic ileus

DOID EFO Endpoint Browser PheWeb

K11_PARALIL

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — K56.0
  • Hospital discharge: ICD-9 — 5601
  • Hospital discharge: ICD-8 — 5601
  • Cause of death: ICD-10 — K56.0
  • Cause of death: ICD-9 — 5601
  • Cause of death: ICD-8 — 5601

2 out of 7 registries used, show all original rules.

1299

4. Check minimum number of events

None

1299

5. Include endpoints

None

1299

6. Filter based on genotype QC (FinnGen only)

1252

Control definitions (FinnGen only)

Control exclude K11_INTESTOTH

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 K56
Name in latin Ileus paralyticus

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 14781 6910 7679
Only index persons 10923 5151 5772
Unadjusted period prevalence (%)
Whole population 0.21 0.20 0.21
Only index persons 0.21 0.19 0.22
Median age at first event (years)
Whole population 69.57 71.39 67.87
Only index persons 67.70 68.98 66.55

-FinnGen-

Key figures

All Female Male
Number of individuals 1252 492 760
Unadjusted period prevalence (%) 0.31 0.19 0.38
Median age at first event (years) 63.88 57.20 68.22

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint K11_PARALIL and mortality.

Females

Parameter HR [95% CI] p-value
K11_PARALIL 2.533 [2.23, 2.88] < 0.001
Birth year 0.998 [0.99, 1.01] 0.579

During the follow-up period (1.1.1998 — 31.12.2019), 2314 out of 4524 females with K11_PARALIL died.

Males

Parameter HR [95% CI] p-value
K11_PARALIL 2.649 [2.29, 3.06] < 0.001
Birth year 0.991 [0.98, 1.0] 0.058

During the follow-up period (1.1.1998 — 31.12.2019), 2547 out of 5124 males with K11_PARALIL died.

Mortality risk

Mortality risk for people of age

years, who have K11_PARALIL.

N-year risk Females Males
1 0.224% 0.448%
5 1.583% 3.002%
10 4.255% 7.579%
15 7.703% 15.068%
20 13.363% 25.371%

Relationships between endpoints

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Index endpoint: K11_PARALIL – Paralytic ileus

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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