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Intestinal adhesions without obstruction

DOID EFO Endpoint Browser PheWeb

K11_ADHE

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — K56.5
  • Hospital discharge: ICD-9 — 5608A
  • Hospital discharge: ICD-8 — 5609[5-6]
  • Hospital discharge: excluded ICD-8 — 5609[5-6]
  • Cause of death: ICD-10 — K56.5
  • Cause of death: ICD-9 — 5608A
  • Cause of death: ICD-8 — 5609[5-6]
  • Cause of death: excluded ICD-8 — 5609[5-6]

2 out of 7 registries used, show all original rules.

2950

4. Check minimum number of events

None

2950

5. Include endpoints

None

2950

6. Filter based on genotype QC (FinnGen only)

2829

Control definitions (FinnGen only)

Control exclude K11_INTESTOTH

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 K56
Name in latin Ileus ex adhaesionibus intestini

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 24458 13762 10441
Only index persons 20061 11585 8476
Unadjusted period prevalence (%)
Whole population 0.35 0.39 0.29
Only index persons 0.38 0.43 0.32
Median age at first event (years)
Whole population 66.03 66.11 65.89
Only index persons 64.45 64.29 64.66

-FinnGen-

Key figures

All Female Male
Number of individuals 2829 1535 1294
Unadjusted period prevalence (%) 0.62 0.60 0.65
Median age at first event (years) 62.40 58.50 67.03

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint K11_ADHE and mortality.

Females

Parameter HR [95% CI] p-value
K11_ADHE 1.818 [1.63, 2.03] < 0.001
Birth year 0.992 [0.98, 1.0] 0.072

During the follow-up period (1.1.1998 — 31.12.2019), 2773 out of 8045 females with K11_ADHE died.

Males

Parameter HR [95% CI] p-value
K11_ADHE 1.885 [1.65, 2.15] < 0.001
Birth year 0.986 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 2238 out of 6374 males with K11_ADHE died.

Mortality risk

Mortality risk for people of age

years, who have K11_ADHE.

N-year risk Females Males
1 0.151% 0.27%
5 1.043% 2.11%
10 2.691% 5.055%
15 4.838% 9.029%
20 8.175% 15.956%

Relationships between endpoints

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Index endpoint: K11_ADHE – Intestinal adhesions without obstruction

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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