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Other or unspecified ileus, impaction or obstruction

DOID EFO Endpoint Browser PheWeb

K11_OTHILEUS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — K56.4, K56.6, K56.7
  • Hospital discharge: ICD-9 — 5608|5609
  • Hospital discharge: ICD-8 — 5609
  • Hospital discharge: excluded ICD-9 — 5608A
  • Cause of death: ICD-10 — K56.4, K56.6, K56.7
  • Cause of death: ICD-9 — 5608|5609
  • Cause of death: ICD-8 — 5609
  • Cause of death: excluded ICD-9 — 5608A

2 out of 7 registries used, show all original rules.

7381

4. Check minimum number of events

None

7381

5. Include endpoints

None

7381

6. Filter based on genotype QC (FinnGen only)

7122

Control definitions (FinnGen only)

Control exclude K11_INTESTOTH

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 77370 39030 37319
Only index persons 56491 28754 27737
Unadjusted period prevalence (%)
Whole population 1.08 1.12 1.04
Only index persons 1.06 1.06 1.06
Median age at first event (years)
Whole population 68.71 70.35 66.98
Only index persons 66.98 68.35 65.57

-FinnGen-

Key figures

All Female Male
Number of individuals 7122 3209 3913
Unadjusted period prevalence (%) 1.65 1.26 1.97
Median age at first event (years) 64.24 61.39 66.58

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint K11_OTHILEUS and mortality.

Females

Parameter HR [95% CI] p-value
K11_OTHILEUS 2.598 [2.35, 2.87] < 0.001
Birth year 0.997 [0.99, 1.0] 0.489

During the follow-up period (1.1.1998 — 31.12.2019), 12605 out of 24341 females with K11_OTHILEUS died.

Males

Parameter HR [95% CI] p-value
K11_OTHILEUS 2.576 [2.31, 2.87] < 0.001
Birth year 0.987 [0.98, 1.0] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 11756 out of 23689 males with K11_OTHILEUS died.

Mortality risk

Mortality risk for people of age

years, who have K11_OTHILEUS.

N-year risk Females Males
1 0.238% 0.443%
5 1.486% 2.437%
10 4.369% 6.074%
15 7.892% 12.221%
20 13.355% 20.602%

Relationships between endpoints

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Index endpoint: K11_OTHILEUS – Other or unspecified ileus, impaction or obstruction

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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