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Impaction of intestines

DOID EFO Endpoint Browser PheWeb

K11_IMPACT

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — K56.3, K56.4
  • Hospital discharge: ICD-9 — 5603
  • Hospital discharge: ICD-8 — 5603
  • Cause of death: ICD-10 — K56.3, K56.4
  • Cause of death: ICD-9 — 5603
  • Cause of death: ICD-8 — 5603

2 out of 7 registries used, show all original rules.

227

4. Check minimum number of events

None

227

5. Include endpoints

None

227

6. Filter based on genotype QC (FinnGen only)

221

Control definitions (FinnGen only)

Control exclude K11_INTESTOTH

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3077 1658 1372
Only index persons 1888 1071 817
Unadjusted period prevalence (%)
Whole population 0.04 0.05 0.04
Only index persons 0.04 0.04 0.03
Median age at first event (years)
Whole population 66.50 69.86 62.39
Only index persons 59.60 63.66 54.27

-FinnGen-

Key figures

All Female Male
Number of individuals 221 118 103
Unadjusted period prevalence (%) 0.05 0.05 0.05
Median age at first event (years) 58.10 54.38 62.37

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint K11_IMPACT and mortality.

Females

Parameter HR [95% CI] p-value
K11_IMPACT 1.676 [1.35, 2.08] < 0.001
Birth year 0.993 [0.98, 1.0] 0.109

During the follow-up period (1.1.1998 — 31.12.2019), 288 out of 744 females with K11_IMPACT died.

Males

Parameter HR [95% CI] p-value
K11_IMPACT 2.113 [1.56, 2.85] < 0.001
Birth year 0.984 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 212 out of 515 males with K11_IMPACT died.

Mortality risk

Mortality risk for people of age

years, who have K11_IMPACT.

N-year risk Females Males
1 0.154% 0.352%
5 0.97% 2.227%
10 2.367% 5.192%
15 4.398% 10.302%
20 7.868% 16.948%

Relationships between endpoints

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Index endpoint: K11_IMPACT – Impaction of intestines

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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