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Volvulus

DOID EFO Endpoint Browser PheWeb

K11_VOLVU

intestinal volvulus: A twisting in the intestine (INTESTINES) that can cause INTESTINAL OBSTRUCTION.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — K56.2
  • Hospital discharge: ICD-9 — 5602
  • Hospital discharge: ICD-8 — 5602
  • Cause of death: ICD-10 — K56.2
  • Cause of death: ICD-9 — 5602
  • Cause of death: ICD-8 — 5602

2 out of 7 registries used, show all original rules.

876

4. Check minimum number of events

None

876

5. Include endpoints

None

876

6. Filter based on genotype QC (FinnGen only)

841

Control definitions (FinnGen only)

Control exclude K11_INTESTOTH

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 K56
Name in latin Volvulus

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 10166 5114 4937
Only index persons 7288 3806 3482
Unadjusted period prevalence (%)
Whole population 0.14 0.15 0.14
Only index persons 0.14 0.14 0.13
Median age at first event (years)
Whole population 67.42 67.45 67.29
Only index persons 64.90 64.27 65.59

-FinnGen-

Key figures

All Female Male
Number of individuals 841 441 400
Unadjusted period prevalence (%) 0.19 0.17 0.20
Median age at first event (years) 64.00 58.49 70.08

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint K11_VOLVU and mortality.

Females

Parameter HR [95% CI] p-value
K11_VOLVU 2.403 [2.02, 2.85] < 0.001
Birth year 0.992 [0.98, 1.0] 0.072

During the follow-up period (1.1.1998 — 31.12.2019), 987 out of 2695 females with K11_VOLVU died.

Males

Parameter HR [95% CI] p-value
K11_VOLVU 2.982 [2.43, 3.66] < 0.001
Birth year 0.987 [0.98, 1.0] 0.007

During the follow-up period (1.1.1998 — 31.12.2019), 1155 out of 2529 males with K11_VOLVU died.

Mortality risk

Mortality risk for people of age

years, who have K11_VOLVU.

N-year risk Females Males
1 0.238% 0.727%
5 1.241% 3.817%
10 3.134% 8.8%
15 5.608% 16.461%
20 9.739% 26.494%

Relationships between endpoints

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Index endpoint: K11_VOLVU – Volvulus

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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