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Other functional intestinal disorders

DOID EFO Endpoint Browser PheWeb

K11_OTHFUNC

intestinal disease: A non-neoplastic or neoplastic disorder that affects the small or large intestine.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — K59
  • Hospital discharge: ICD-9 — 564
  • Hospital discharge: ICD-8 — 564
  • Hospital discharge: excluded ICD-9 — 5641|564[3-4]
  • Hospital discharge: excluded ICD-8 — 56419
  • Cause of death: ICD-10 — K59
  • Cause of death: ICD-9 — 564
  • Cause of death: ICD-8 — 564

2 out of 7 registries used, show all original rules.

21182

4. Check minimum number of events

None

21182

5. Include endpoints

None

21182

6. Filter based on genotype QC (FinnGen only)

20342

Control definitions (FinnGen only)

Control exclude K11_INTESTOTH

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 K55-K63
Name in latin Aliae dysfunctiones intestinalis

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 238569 134150 102492
Only index persons 182452 105836 76616
Unadjusted period prevalence (%)
Whole population 3.41 3.84 2.86
Only index persons 3.49 3.89 2.92
Median age at first event (years)
Whole population 59.67 60.81 57.98
Only index persons 58.09 59.31 56.40

-FinnGen-

Key figures

All Female Male
Number of individuals 20342 12253 8089
Unadjusted period prevalence (%) 4.51 4.81 4.06
Median age at first event (years) 60.95 56.50 67.68

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint K11_OTHFUNC and mortality.

Females

Parameter HR [95% CI] p-value
K11_OTHFUNC 1.782 [1.62, 1.96] < 0.001
Birth year 0.993 [0.99, 1.0] 0.072

During the follow-up period (1.1.1998 — 31.12.2019), 27135 out of 96886 females with K11_OTHFUNC died.

Males

Parameter HR [95% CI] p-value
K11_OTHFUNC 2.061 [1.84, 2.31] < 0.001
Birth year 0.986 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 23078 out of 72376 males with K11_OTHFUNC died.

Mortality risk

Mortality risk for people of age

years, who have K11_OTHFUNC.

N-year risk Females Males
1 0.177% 0.331%
5 0.96% 2.022%
10 2.286% 4.963%
15 4.263% 9.369%
20 7.488% 15.742%

Relationships between endpoints

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Index endpoint: K11_OTHFUNC – Other functional intestinal disorders

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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